Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLHL2
  • Mouse genes Klhl2
  • Rat genes Klhl2
  • Zfish genes klhl2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klhl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	KLHL2	IDA		Human	PMID:10397770
Molecular Function	GO:0042802	identical protein binding	KLHL2	IPI	UniProtKB:O95198	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	KLHL2	IPI	UniProtKB:O95198	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	KLHL2	IPI	UniProtKB:O95198	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q53G59	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q13618	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q53G59	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:P26651	Human	PMID:21784977
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:O00560	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:O14787	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:O95881	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:P49760	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:P50895	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q13618	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q5TZN3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q86WV7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q8NC26	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q96EY4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q96MW1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:P50895	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:O14787	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:O95881	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q13618	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q8NC26	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q96EY4	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:P49760	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:P55081	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q13895	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q14145	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q14241	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q16543	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q4G0R1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q53G59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q6TGC4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q7KZS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q86XT4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q8NC26	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q96EY4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q9BUI4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q9H1P6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q9HCG8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q9UH77	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL2	IPI	UniProtKB:Q9ULW6	Human	PMID:32296183
Cellular Component	GO:0015629	actin cytoskeleton	KLHL2	IDA		Human	PMID:10397770
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	Klhl2	IDA		Mouse	MGI:MGI:5296724|PMID:21549840
Cellular Component	GO:0005737	cytoplasm	Klhl2	IDA		Mouse	MGI:MGI:5296724|PMID:21549840
Biological Process	GO:0016567	protein ubiquitination	Klhl2	IDA		Mouse	MGI:MGI:5296724|PMID:21549840

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern