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Klhl2 Gene Detail
Summary
  • Symbol
    Klhl2
  • Name
    kelch-like 2, Mayven
  • Synonyms
    6030411N21Rik, 8530402H02Rik, ABP-KELCH, Mav
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924363
    NCBI Gene: 77113
  • Gene Overview
    MyGene.info: KLHL2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:64739675-64850017 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 32.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    534 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924363
protein coding gene Chr8:64739673-64850029 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033644
protein coding gene Chr8:64760210-64872346 (-)
A/J MGP_AJ_G0033626
protein coding gene Chr8:62028923-62141828 (-)
AKR/J MGP_AKRJ_G0033551
protein coding gene Chr8:63796792-63904878 (-)
BALB/cJ MGP_BALBcJ_G0033622
protein coding gene Chr8:62312010-62422981 (-)
C3H/HeJ MGP_C3HHeJ_G0033332
protein coding gene Chr8:64536681-64647145 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034139
protein coding gene Chr8:67174476-67291012 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031086
protein coding gene Chr8:57302447-57408470 (-)
CAST/EiJ MGP_CASTEiJ_G0032657
protein coding gene Chr8:63986017-64096607 (-)
CBA/J MGP_CBAJ_G0033310
protein coding gene Chr8:69685919-69801650 (-)
DBA/2J MGP_DBA2J_G0033464
protein coding gene Chr8:61847640-61957556 (-)
FVB/NJ MGP_FVBNJ_G0033405
protein coding gene Chr8:61066522-61174325 (-)
LP/J MGP_LPJ_G0033552
protein coding gene Chr8:64798907-64912504 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033449
protein coding gene Chr8:72237487-72353958 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034157
protein coding gene Chr8:64092167-64203783 (-)
PWK/PhJ MGP_PWKPhJ_G0032366
protein coding gene Chr8:61176340-61383839 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032202
protein coding gene Chr8:63074643-63191731 (-)
WSB/EiJ MGP_WSBEiJ_G0032774
protein coding gene Chr8:64477222-64585403 (-)



Homology
more
  • Human Ortholog
    KLHL2, kelch like family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLHL2, kelch like family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABP-KELCH, MAV, MAYVEN
  • Links
    NCBI Gene ID: 11275
    neXtProt AC: NX_O95198
    UniProt: O95198

  • Chr Location
    4q32.3; chr4:165207618-165323156 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031605 Ensembl Gene Model | MGI Sequence Detail 110343 C57BL/6J ±  kb
transcript ENSMUST00000210166 Ensembl | MGI Sequence Detail 5126 Not Applicable  
polypeptide ENSMUSP00000147262 Ensembl | MGI Sequence Detail 603 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:1925485, MGI:2142725
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:47397 Soltysik-Espanola M, et al., Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. Mol Biol Cell. 1999 Jul;10(7):2361-75
  • Latest
    J:250869 Kasagi Y, et al., Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice. Biochem Biophys Res Commun. 2017 May 27;487(2):368-374

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory