Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KDM4A
  • Mouse genes Kdm4a
  • Rat genes Kdm4a
  • Zfish genes kdm4aa,kdm4ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kdm4a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032452	histone demethylase activity	Kdm4a	IDA		Mouse	PMID:19144645
Molecular Function	GO:0051864	histone H3K36 demethylase activity	KDM4A	IDA		Human	PMID:16024779
Molecular Function	GO:0051864	histone H3K36 demethylase activity	KDM4A	IDA		Human	PMID:21914792
Molecular Function	GO:0032454	histone H3K9 demethylase activity	Kdm4a	IDA		Mouse	PMID:16738407
Molecular Function	GO:0140684	histone H3K9me2/H3K9me3 demethylase activity	KDM4A	IMP		Human	PMID:21914792
Molecular Function	GO:0035064	methylated histone binding	KDM4A	IDA		Human	PMID:22373579
Molecular Function	GO:0005515	protein binding	KDM4A	IPI	UniProtKB:P62805	Human	PMID:16415788
Molecular Function	GO:0005515	protein binding	KDM4A	IPI	UniProtKB:P68431	Human	PMID:16415788
Molecular Function	GO:0005515	protein binding	KDM4A	IPI	UniProtKB:P68431	Human	PMID:16603238
Molecular Function	GO:0005515	protein binding	KDM4A	IPI	UniProtKB:Q16695	Human	PMID:17567753
Molecular Function	GO:0005515	protein binding	KDM4A	IPI	UniProtKB:P62805	Human	PMID:22373579
Molecular Function	GO:0005515	protein binding	KDM4A	IPI	UniProtKB:P11308	Human	PMID:27109047
Molecular Function	GO:0031625	ubiquitin protein ligase binding	KDM4A	IPI	UniProtKB:O76064	Human	PMID:22373579
Molecular Function	GO:0031625	ubiquitin protein ligase binding	KDM4A	IPI	UniProtKB:Q8IYW5	Human	PMID:22373579
Molecular Function	GO:0008270	zinc ion binding	KDM4A	IDA		Human	PMID:27214403
Cellular Component	GO:0005737	cytoplasm	Kdm4a	IDA		Rat	PMID:15927959|RGD:9587432
Cellular Component	GO:0005829	cytosol	KDM4A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001650	fibrillar center	KDM4A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KDM4A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	KDM4A	IDA		Human	PMID:16024779
Cellular Component	GO:0005634	nucleus	KDM4A	IMP		Human	PMID:21914792
Cellular Component	GO:0005634	nucleus	Kdm4a	IDA		Rat	PMID:15927959|RGD:9587432
Cellular Component	GO:0005721	pericentric heterochromatin	Kdm4a	IDA		Mouse	PMID:16738407
Biological Process	GO:0030263	apoptotic chromosome condensation	Kdm4a	IMP		Rat	PMID:24747049|RGD:9587433
Biological Process	GO:0048514	blood vessel morphogenesis	kdm4ab	IMP	ZFIN:ZDB-MRPHLNO-151123-4	Zfish	PMID:26120059
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	Kdm4a	IMP		Mouse	PMID:21555854
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	Kdm4a	IMP		Rat	PMID:24747049|RGD:9587433
Biological Process	GO:0010507	negative regulation of autophagy	KDM4A	IMP		Human	PMID:25660547
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	KDM4A	IDA		Human	PMID:16024779
Biological Process	GO:0010629	negative regulation of gene expression	KDM4A	IMP		Human	PMID:25660547
Biological Process	GO:0010628	positive regulation of gene expression	Kdm4a	IMP		Rat	PMID:24747049|RGD:9587433
Biological Process	GO:0045666	positive regulation of neuron differentiation	Kdm4a	IMP		Rat	PMID:24747049|RGD:9587433
Biological Process	GO:0031667	response to nutrient levels	Kdm4a	IEP		Rat	PMID:21372147|RGD:9587423

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern