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Kdm4a Gene Detail
Summary
  • Symbol
    Kdm4a
  • Name
    lysine (K)-specific demethylase 4A
  • Synonyms
    D4Ertd222e, JHDM3A, Jmjd2, Jmjd2a, MGC:28562, mKIAA0677
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446210
    NCBI Gene: 230674
  • Gene Overview
    MyGene.info: KDM4A
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:118136957-118180043 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 54.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    312 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446210
protein coding gene Chr4:118136957-118180043 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028663
protein coding gene Chr4:119163791-119208091 (-)
A/J MGP_AJ_G0028624
protein coding gene Chr4:114562856-114607460 (-)
AKR/J MGP_AKRJ_G0028574
protein coding gene Chr4:117070578-117114248 (-)
BALB/cJ MGP_BALBcJ_G0028645
protein coding gene Chr4:115194746-115240994 (-)
C3H/HeJ MGP_C3HHeJ_G0028359
protein coding gene Chr4:118639817-118685473 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029086
protein coding gene Chr4:123738891-123786387 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026370
protein coding gene Chr4:108584739-108629936 (-)
CAST/EiJ MGP_CASTEiJ_G0027793
protein coding gene Chr4:115886880-115933086 (-)
CBA/J MGP_CBAJ_G0028326
protein coding gene Chr4:127116468-127174070 (-)
DBA/2J MGP_DBA2J_G0028474
protein coding gene Chr4:115174387-115216862 (-)
FVB/NJ MGP_FVBNJ_G0028442
protein coding gene Chr4:113688893-113735085 (-)
LP/J MGP_LPJ_G0028576
protein coding gene Chr4:119348608-119393564 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028469
protein coding gene Chr4:132037890-132082959 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029123
protein coding gene Chr4:118229134-118271838 (-)
PWK/PhJ MGP_PWKPhJ_G0027519
protein coding gene Chr4:112004134-112046349 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027342
protein coding gene Chr4:114529321-114573619 (-)
WSB/EiJ MGP_WSBEiJ_G0027872
protein coding gene Chr4:118102405-118147876 (-)



Homology
more
  • Human Ortholog
    KDM4A, lysine demethylase 4A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KDM4A, lysine demethylase 4A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    JHDM3A, JMJD2, JMJD2A, TDRD14A
  • Links
    NCBI Gene ID: 9682
    neXtProt AC: NX_O75164
    UniProt: O75164

  • Chr Location
    1p34.2-p34.1; chr1:43650118-43705518 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 27780
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KDM4A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    2 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230674 NCBI Gene Model | MGI Sequence Detail 43087 C57BL/6J ±  kb
    transcript NM_001161823 RefSeq | MGI Sequence Detail 4616 C57BL/6  
    polypeptide Q8BW72 UniProt | EBI | MGI Sequence Detail 1064 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 59
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1098782
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:260916 Zhou J, et al., The histone demethylase JMJD2A regulates the expression of BDNF and mediates neuropathic pain in mice. Exp Cell Res. 2017 Dec 1;361(1):155-162

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory