Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNA2
  • Mouse genes Kcna2
  • Rat genes Kcna2
  • Zfish genes kcna2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcna2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	Kcna2	IMP		Rat	PMID:19713757|RGD:10047171
Molecular Function	GO:0019894	kinesin binding	Kcna2	IPI	RGD:621559	Rat	PMID:17241275|RGD:11059543
Molecular Function	GO:0015271	outward rectifier potassium channel activity	Kcna2	IMP		Rat	PMID:12127166|RGD:1581351
Molecular Function	GO:0005515	protein binding	KCNA2	IPI	UniProtKB:P49069	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Kcna2	IPI	UniProtKB:Q9R0C9	Mouse	MGI:MGI:5493175|PMID:23332758
Molecular Function	GO:0005515	protein binding	Kcna2	IPI	UniProtKB:O55242	Mouse	MGI:MGI:5493175|PMID:23332758
Molecular Function	GO:0005515	protein binding	Kcna2	IPI	UniProtKB:Q9R1V4	Mouse	MGI:MGI:5695673|PMID:26269648
Molecular Function	GO:0005515	protein binding	Kcna2	IPI	UniProtKB:Q60598	Mouse	MGI:MGI:5607241|PMID:17959782
Molecular Function	GO:0005515	protein binding	Kcna2	IPI	UniProtKB:Q9CPW0	Mouse	PMID:21632923
Molecular Function	GO:0005515	protein binding	Kcna2	IPI	UniProtKB:Q9CPW0	Mouse	PMID:25707359
Molecular Function	GO:0005515	protein binding	Kcna2	IPI	PR:Q61330	Mouse	PMID:20962216
Molecular Function	GO:0005515	protein binding	Kcna2	IPI	RGD:1307076	Rat	PMID:10624965|RGD:8554062
Molecular Function	GO:0005515	protein binding	Kcna2	IPI	UniProtKB:P78352	Rat	PMID:7477295|RGD:8554588
Molecular Function	GO:1905030	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Kcna2	IDA		Rat	PMID:12777451|RGD:155230739
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Kcna2	EXP		Rat	PMID:12777451|RGD:155230739
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Kcna2	IDA		Rat	PMID:12777451|RGD:155230739
Molecular Function	GO:0005249	voltage-gated potassium channel activity	KCNA2	IMP		Human	PMID:19912772
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Kcna2	IDA		Mouse	MGI:MGI:4947004|PMID:21233214
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Kcna2	IMP		Rat	PMID:2555158|RGD:69870
Cellular Component	GO:0030424	axon	Kcna2	IDA		Mouse	MGI:MGI:4947004|PMID:21233214
Cellular Component	GO:0043194	axon initial segment	Kcna2	IDA		Mouse	PMID:18509034
Cellular Component	GO:0043679	axon terminus	Kcna2	IDA		Mouse	MGI:MGI:4947004|PMID:21233214
Cellular Component	GO:0044305	calyx of Held	Kcna2	EXP		Rat	PMID:12777451|RGD:155230739
Cellular Component	GO:0044305	calyx of Held	Kcna2	IDA		Rat	PMID:12777451|RGD:155230739
Cellular Component	GO:0044305	calyx of Held	Kcna2	IDA		Rat	PMID:14614103|RGD:13702408
Cellular Component	GO:0030425	dendrite	Kcna2	IDA		Mouse	MGI:MGI:67695|PMID:8046438
Cellular Component	GO:0098978	glutamatergic synapse	Kcna2	EXP		Rat	PMID:12777451|RGD:155230739
Cellular Component	GO:0098978	glutamatergic synapse	Kcna2	IDA		Rat	PMID:12777451|RGD:155230739
Cellular Component	GO:0098978	glutamatergic synapse	Kcna2	IDA		Rat	PMID:14614103|RGD:13702408
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcna2	IDA		Mouse	MGI:MGI:2675531|PMID:12963709
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcna2	IDA		Mouse	MGI:MGI:3617955|PMID:16525039
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcna2	IDA		Mouse	MGI:MGI:5613863|PMID:25378149
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcna2	IDA		Mouse	PMID:15102918
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcna2	IDA		Mouse	PMID:18760366
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcna2	IDA		Rat	PMID:10624965|RGD:8554062
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcna2	IDA		Rat	PMID:20089912|RGD:10047376
Cellular Component	GO:0030027	lamellipodium	Kcna2	IDA		Rat	PMID:12151401|RGD:10047206
Cellular Component	GO:0032809	neuronal cell body membrane	Kcna2	IDA		Mouse	MGI:MGI:67695|PMID:8046438
Cellular Component	GO:0043204	perikaryon	Kcna2	IDA		Mouse	MGI:MGI:67695|PMID:8046438
Cellular Component	GO:0005886	plasma membrane	KCNA2	IMP		Human	PMID:19912772
Cellular Component	GO:0005886	plasma membrane	Kcna2	IMP		Mouse	MGI:MGI:4947004|PMID:21233214
Cellular Component	GO:0005886	plasma membrane	Kcna2	IMP		Rat	PMID:2555158|RGD:69870
Cellular Component	GO:0045211	postsynaptic membrane	Kcna2	IDA		Rat	PMID:14614103|RGD:13702408
Cellular Component	GO:0034705	potassium channel complex	Kcna2	IDA		Rat	PMID:9334400|RGD:10047182
Cellular Component	GO:0042734	presynaptic membrane	Kcna2	IDA		Rat	PMID:14614103|RGD:13702408
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNA2	IDA		Human	PMID:11086297
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcna2	IDA		Mouse	MGI:MGI:2675529|PMID:12975355
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcna2	IMP		Rat	PMID:12177193|RGD:10047355
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcna2	IDA		Rat	PMID:23705070|RGD:10047260
Biological Process	GO:0021987	cerebral cortex development	Kcna2	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0022038	corpus callosum development	Kcna2	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0019228	neuronal action potential	Kcna2	IMP		Rat	PMID:12177193|RGD:10047355
Biological Process	GO:0021554	optic nerve development	Kcna2	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0021633	optic nerve structural organization	Kcna2	IMP	MGI:MGI:3043422	Mouse	PMID:15102918
Biological Process	GO:0097623	potassium ion export across plasma membrane	Kcna2	IMP		Rat	PMID:12127166|RGD:1581351
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNA2	IMP		Human	PMID:19912772
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcna2	IDA		Mouse	MGI:MGI:4947004|PMID:21233214
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcna2	IMP		Rat	PMID:2555158|RGD:69870
Biological Process	GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep	Kcna2	IMP		Mouse	MGI:MGI:3770734|PMID:17925011
Biological Process	GO:0014059	regulation of dopamine secretion	Kcna2	IMP		Mouse	MGI:MGI:4947004|PMID:21233214
Biological Process	GO:0019233	sensory perception of pain	Kcna2	IMP		Rat	PMID:24472174|RGD:10047141

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern