Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITM2B
  • Mouse genes Itm2b
  • Rat genes Itm2b
  • Zfish genes itm2ba,itm2bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itm2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ITM2B	IPI	UniProtKB:P05067	Human	PMID:19849849
Molecular Function	GO:0005524	ATP binding	Itm2b	IDA		Mouse	PMID:10679242
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:P05067	Human	PMID:16027166
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:P05067-8	Human	PMID:16027166
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:Q8TCT7	Human	PMID:17965014
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:Q8TCT8	Human	PMID:17965014
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:P56817	Human	PMID:23701002
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:Q58DX5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:Q8N205	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:Q8N6L0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:Q9NRM0-1	Human	PMID:31695625
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:Q9NRM0-2	Human	PMID:31695625
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:P26715	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ITM2B	IPI	UniProtKB:Q96E17	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Itm2b	IPI	UniProtKB:P07825	Rat	PMID:29476059|RGD:42721991
Molecular Function	GO:0005515	protein binding	Itm2b	IPI	UniProtKB:P07936	Rat	PMID:29476059|RGD:42721991
Molecular Function	GO:0005515	protein binding	Itm2b	IPI	UniProtKB:P31016	Rat	PMID:29476059|RGD:42721991
Cellular Component	GO:0070062	extracellular exosome	ITM2B	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ITM2B	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	ITM2B	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ITM2B	IDA		Human	PMID:18524908
Cellular Component	GO:0005794	Golgi apparatus	ITM2B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030660	Golgi-associated vesicle membrane	ITM2B	IDA		Human	PMID:17965014
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ITM2B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	ITM2B	HDA		Human	PMID:19946888
Cellular Component	GO:0031090	organelle membrane	ITM2B	IDA		Human	PMID:10526337
Cellular Component	GO:0005886	plasma membrane	ITM2B	IDA		Human	PMID:19114711
Cellular Component	GO:0005886	plasma membrane	ITM2B	IDA		Human	PMID:22194595
Biological Process	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process	ITM2B	IDA		Human	PMID:16027166
Biological Process	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process	ITM2B	IDA		Human	PMID:18524908

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern