Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITK
  • Mouse genes Itk
  • Rat genes Itk
  • Zfish genes itk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ITK	IDA		Human	PMID:12186560
Molecular Function	GO:0005515	protein binding	ITK	IPI	UniProtKB:O43561	Human	PMID:12186560
Molecular Function	GO:0005515	protein binding	ITK	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ITK	IPI	UniProtKB:Q13094	Human	PMID:17420479
Molecular Function	GO:0005515	protein binding	ITK	IPI	UniProtKB:P10686	Human	PMID:18443296
Molecular Function	GO:0005515	protein binding	ITK	IPI	UniProtKB:P48023	Human	PMID:19807924
Molecular Function	GO:0005515	protein binding	ITK	IPI	UniProtKB:Q13094	Human	PMID:21725281
Molecular Function	GO:0005515	protein binding	ITK	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	ITK	IPI	UniProtKB:P08238	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ITK	IPI	UniProtKB:P10686	Human	PMID:31585087
Molecular Function	GO:0005515	protein binding	ITK	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	ITK	IPI	UniProtKB:P42768	Human	PMID:8892607
Molecular Function	GO:0005515	protein binding	Itk	IPI	UniProtKB:Q8BGW0	Mouse	MGI:MGI:4352756|PMID:19597499
Molecular Function	GO:0005515	protein binding	Itk	IPI	UniProtKB:Q9JKD8	Mouse	MGI:MGI:5917559|PMID:15662016
Molecular Function	GO:0005515	protein binding	Itk	IPI	UniProtKB:P08487	Mouse	MGI:MGI:6093204|PMID:19955438
Cellular Component	GO:0005911	cell-cell junction	Itk	IDA		Mouse	PMID:23793062
Cellular Component	GO:0005829	cytosol	ITK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Itk	IDA		Mouse	MGI:MGI:5917559|PMID:15662016
Cellular Component	GO:0005886	plasma membrane	ITK	IDA		Human	GO_REF:0000052
Biological Process	GO:0007202	activation of phospholipase C activity	Itk	IMP		Mouse	MGI:MGI:1335923|PMID:10213685
Biological Process	GO:0002250	adaptive immune response	Itk	IMP		Mouse	MGI:MGI:1335923|PMID:10213685
Biological Process	GO:0046629	gamma-delta T cell activation	Itk	IMP		Mouse	MGI:MGI:5486619|PMID:23562159
Biological Process	GO:0032633	interleukin-4 production	Itk	IMP	MGI:MGI:2178928	Mouse	PMID:18292523
Biological Process	GO:0032633	interleukin-4 production	Itk	IGI	MGI:MGI:102960	Mouse	PMID:18292523
Biological Process	GO:0001865	NK T cell differentiation	Itk	IMP	MGI:MGI:2178928	Mouse	PMID:18292523
Biological Process	GO:0001865	NK T cell differentiation	Itk	IGI	MGI:MGI:102960	Mouse	PMID:18292523
Biological Process	GO:0001819	positive regulation of cytokine production	Itk	IMP		Mouse	MGI:MGI:1335923|PMID:10213685
Biological Process	GO:0006468	protein phosphorylation	Itk	IMP		Mouse	MGI:MGI:5917559|PMID:15662016
Biological Process	GO:0050852	T cell receptor signaling pathway	Itk	IMP		Mouse	MGI:MGI:1335923|PMID:10213685
Biological Process	GO:0032609	type II interferon production	Itk	IMP	MGI:MGI:2178928	Mouse	PMID:18292523
Biological Process	GO:0032609	type II interferon production	Itk	IGI	MGI:MGI:102960	Mouse	PMID:18292523

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern