| GO term: | NK T cell differentiation |
| Synonym: | natural killer T cell differentiation |
| Synonym: | natural T cell differentiation |
| Synonym: | NK T cell development |
| Synonym: | NK T-cell differentiation |
| Synonym: | NKT cell differentiation |
| Synonym: | NK T lymphocyte differentiation |
| Synonym: | NK T-lymphocyte differentiation |
| Synonym: | NT cell differentiation |
| GO id: | GO:0001865 |
| Definition: | The process in which a precursor cell type acquires the specialized features of a NK T cell. |
| Comments | Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. |
| Number of paths to term: | 24 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationalpha-beta T cell activationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processanatomical structure developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processdevelopmental processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processimmune system processimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationT cell activationalpha-beta T cell activationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationT cell activationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationalpha-beta T cell activationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +biological_processsingle-organism processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationT cell differentiationalpha-beta T cell differentiationalpha-beta intraepithelial T cell differentiation +alpha-beta T cell differentiation involved in immune response +alpha-beta T cell lineage commitment +beta selectionCD4-positive, alpha-beta T cell differentiation +CD8-positive, alpha-beta T cell differentiation +negative regulation of alpha-beta T cell differentiation +NK T cell differentiation [GO:0001865] (7 genes, 8 annotations)negative regulation of NK T cell differentiationNK T cell lineage commitmentpositive regulation of NK T cell differentiationregulation of NK T cell differentiation +positive regulation of alpha-beta T cell differentiation +regulation of alpha-beta T cell differentiation +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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