Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRX5
  • Mouse genes Irx5
  • Rat genes Irx5
  • Zfish genes irx5a,irx5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irx5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IRX5	IDA		Human	PMID:28473536
Biological Process	GO:0048468	cell development	Irx5	IMP	MGI:MGI:3610374	Mouse	PMID:16182275
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IRX5	IMP		Human	PMID:22581230
Biological Process	GO:0072498	embryonic skeletal joint development	irx5a	IGI	ZFIN:ZDB-GENO-160325-6	Zfish	PMID:26555055
Biological Process	GO:0008406	gonad development	IRX5	IMP		Human	PMID:22581230
Biological Process	GO:0042551	neuron maturation	Irx5	IGI	MGI:MGI:1890816	Mouse	PMID:18322081
Biological Process	GO:0032330	regulation of chondrocyte differentiation	irx5a	IGI	ZFIN:ZDB-GENO-160325-6	Zfish	PMID:26555055
Biological Process	GO:0010468	regulation of gene expression	Irx5	IMP	MGI:MGI:3610374	Mouse	PMID:16239150
Biological Process	GO:0002027	regulation of heart rate	Irx5	IMP	MGI:MGI:3610374	Mouse	PMID:16239150
Biological Process	GO:0060040	retinal bipolar neuron differentiation	Irx5	IGI	MGI:MGI:1890816	Mouse	PMID:18322081

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern