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Irx5 Gene Detail
Summary
  • Symbol
    Irx5
  • Name
    Iroquois homeobox 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859086
    NCBI Gene: 54352
  • Gene Overview
    MyGene.info: IRX5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:92357625-92376286 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18662 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 44.93 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    IRX5, iroquois homeobox 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IRX5, iroquois homeobox 5
    Orthology source: HGNC
  • Synonyms
    HMMS, IRX-2a, IRXB2
  • Links
    NCBI Gene ID: 10265
    neXtProt AC: NX_P78411
    UniProt: P78411

  • Chr Location
    16q12.2; chr16:54931199-54934485 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38105
    1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: IRX5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced body size, narrow eye opening, and impaired retinal cone bipolar cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000040089 VEGA Gene Model | MGI Sequence Detail 18662 C57BL/6J ±  kb
    transcript OTTMUST00000150089 VEGA | MGI Sequence Detail 2550 Not Applicable  
    polypeptide OTTMUSP00000077814 VEGA | MGI Sequence Detail 516 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      191 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 34
      Primer pair 2
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 46
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:61328 Cohen DR, et al., Expression of two novel mouse iroquois homeobox genes during neurogenesis. Mech Dev. 2000 Mar 1;91(1-2):317-21
    • Latest
      J:243618 McCracken KW, et al., Wnt/beta-catenin promotes gastric fundus specification in mice and humans. Nature. 2017 Jan 12;541(7636):182-187

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory