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Irx5
Gene Detail
 Symbol
Name
ID
Irx5
Iroquois related homeobox 5 (Drosophila)
MGI:1859086
Feature Type protein coding gene
Genetic Map
Chromosome 8
44.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:92357796-92361456 bp, + strand
From VEGA annotation of GRCm38

  3661 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38105  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Irx5

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced body size, narrow eye opening, and impaired retinal cone bipolar cell development.
 
Interactions
Irx5 interacts with 164 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell development, neuron maturation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (280)    Tissues (148)    Images (59)
Theiler Stages: 12, 15, 17, 18, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 268
In situ reporter (knock in) 3
RT-PCR 9
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(33) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000040089 (Evidence)
Ensembl Gene ModelENSMUSG00000031737 (Evidence)
Entrez Gene54352 (Evidence)
UniGene101153
DFCITC1582044
DoTSDT.527876, DT.97357775
NIA Mouse Gene IndexU009636
Consensus CDS ProjectCCDS22522.1
International Mouse Knockout Project StatusIrx5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040089 VEGA Gene Model | MGI Sequence Detail 3661 C57BL/6J ±  kb
transcript OTTMUST00000104133 VEGA | MGI Sequence Detail 2403 Not Applicable 
polypeptide OTTMUSP00000058246 VEGA | MGI Sequence Detail 484 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003893 Iroquois-class homeodomain protein
Protein Ontology PR:000030461 iroquois-class homeodomain protein IRX-5
References (Earliest) J:61328 Cohen DR, et al., Expression of two novel mouse iroquois homeobox genes during neurogenesis. Mech Dev. 2000 Mar 1;91(1-2):317-21
(Latest) J:197985 Ota H, et al., ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013 Apr 25;153(3):575-89
All references(65)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory