Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IQSEC2
  • Mouse genes Iqsec2
  • Rat genes Iqsec2
  • Zfish genes iqsec2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Iqsec2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IQSEC2	IMP		Human	PMID:26793055
Molecular Function	GO:0005515	protein binding	Iqsec2	IPI	UniProtKB:Q8BKX1	Mouse	MGI:MGI:3842229|PMID:19083995
Cellular Component	GO:0098978	glutamatergic synapse	Iqsec2	IDA		Mouse	PMID:18164504
Cellular Component	GO:0098978	glutamatergic synapse	Iqsec2	IPI		Mouse	PMID:18164504
Cellular Component	GO:0098978	glutamatergic synapse	Iqsec2	IEP		Mouse	PMID:18164504
Cellular Component	GO:0098684	photoreceptor ribbon synapse	Iqsec2	IDA		Mouse	PMID:19811534
Cellular Component	GO:0098839	postsynaptic density membrane	Iqsec2	IDA		Mouse	PMID:18164504
Cellular Component	GO:0098839	postsynaptic density membrane	Iqsec2	IEP		Mouse	PMID:18164504
Cellular Component	GO:0098839	postsynaptic density membrane	Iqsec2	IPI		Mouse	PMID:18164504
Cellular Component	GO:0098839	postsynaptic density membrane	Iqsec2	IMP		Mouse	PMID:18164504
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Iqsec2	IDA		Mouse	PMID:18164504
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Iqsec2	IEP		Mouse	PMID:18164504
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Iqsec2	IPI		Mouse	PMID:18164504
Cellular Component	GO:0098831	presynaptic active zone cytoplasmic component	Iqsec2	IDA		Mouse	PMID:19811534
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IQSEC2	IDA		Human	PMID:27009485
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IQSEC2	IMP		Human	PMID:27009485
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IQSEC2	IDA		Human	PMID:27009485
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IQSEC2	IMP		Human	PMID:27009485
Biological Process	GO:1900454	positive regulation of long-term synaptic depression	Iqsec2	IMP		Rat	PMID:27009485|RGD:11049506
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Iqsec2	IMP		Rat	PMID:27009485|RGD:11049506
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IQSEC2	IDA		Human	PMID:27009485
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IQSEC2	IMP		Human	PMID:27009485

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern