Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL34
  • Mouse genes Il34
  • Rat genes Il34
  • Zfish genes il34
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il34

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005157	macrophage colony-stimulating factor receptor binding	IL34	IDA		Human	PMID:18467591
Molecular Function	GO:0005515	protein binding	IL34	IPI	UniProtKB:Q5T754	Human	PMID:32296183
Cellular Component	GO:0005615	extracellular space	IL34	IDA		Human	PMID:18467591
Biological Process	GO:0061514	interleukin-34-mediated signaling pathway	IL34	IDA		Human	PMID:26754294
Biological Process	GO:1905517	macrophage migration	il34	IMP	ZFIN:ZDB-GENO-200421-8	Zfish	PMID:30724719
Biological Process	GO:0014005	microglia development	il34	IMP	ZFIN:ZDB-GENO-200116-7	Zfish	PMID:30765415
Biological Process	GO:0061518	microglial cell proliferation	Il34	IGI	UniProtKB:P09581	Mouse	MGI:MGI:6274943|PMID:23392676
Biological Process	GO:0008284	positive regulation of cell population proliferation	IL34	IDA		Human	PMID:18467591
Biological Process	GO:0010628	positive regulation of gene expression	Il34	IDA		Mouse	MGI:MGI:6294196|PMID:30687013
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	IL34	IDA		Human	PMID:26754294
Biological Process	GO:0045651	positive regulation of macrophage differentiation	IL34	IDA		Human	PMID:23409120
Biological Process	GO:0120041	positive regulation of macrophage proliferation	IL34	IDA		Human	PMID:26754294
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IL34	IDA		Human	PMID:26754294
Biological Process	GO:0045657	positive regulation of monocyte differentiation	IL34	IDA		Human	PMID:23409120
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Il34	IDA		Mouse	MGI:MGI:5805301|PMID:27445335
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IL34	IDA		Human	PMID:18467591
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	IL34	IDA		Human	PMID:26754294

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern