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Il34
Gene Detail
Symbol

Name
ID
Il34
interleukin 34
MGI:1923777
Synonyms
2010004A03Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
57.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:110741829-110805924 bp, - strand
From VEGA annotation of GRCm38

  64096 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12648  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: IL34
Protein SuperFamily: interleukin-34
Gene Tree: Il34

Human
homologs
IL34, interleukin 34
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 146433
neXtProt AC: NX_Q6ZMJ4

Human Synonyms: C16orf77, IL-34

Human Chr (Location): 16q22.1; chr16:70579895-70660684 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced Langerhans cells and microglial cells in the skin and brain, respectively, with decreased susceptibility to type IV hypersensitivity reaction and fungal infection but increased susceptibility to viral infection.
 
Interactions
Il34 interacts with 48 markers (Mir1b, Mir15a, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process immune system process, inflammatory response, ...
Component extracellular region, extracellular space
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (57)    Tissues (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 56
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(27) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027476 (Evidence)
Ensembl Gene Model ENSMUSG00000031750 (Evidence)
Entrez Gene 76527 (Evidence)
UniGene 77697
DFCI TC1579964, TC1729429, TC1712559
PDB 4EXN, 4EXP
Consensus CDS Project CCDS52669.1, CCDS52670.1
International Mouse Phenotyping Consortium Status Il34
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027476 VEGA Gene Model | MGI Sequence Detail 64096 C57BL/6J ±  kb
transcript OTTMUST00000067998 VEGA | MGI Sequence Detail 1709 Not Applicable 
polypeptide OTTMUSP00000034298 VEGA | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(22) UniProt(1)
Polymorphisms
SNPs within 2kb(125 from dbSNP Build 137)    SNPs within 2kb including multiple locations(129)
Protein-related
information
ResourceIDDescription
InterPro IPR020415 Interleukin-34
Protein Ontology PR:000001390 interleukin-34
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202720 Nandi S, et al., Receptor-type protein-tyrosine phosphatase zeta is a functional receptor for interleukin-34. J Biol Chem. 2013 Jul 26;288(30):21972-86
All references(37)
Other
accession IDs
MGI:2142587

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory