Comparative GO Graph (mouse, human)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL27RA
  • Mouse genes Il27ra
  • Rat genes Il27ra
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il27ra

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045509	interleukin-27 receptor activity	Il27ra	IDA		Mouse	PMID:12121660
Molecular Function	GO:0005515	protein binding	IL27RA	IPI	UniProtKB:Q8IVG9	Human	PMID:19386761
Molecular Function	GO:0005515	protein binding	IL27RA	IPI	UniProtKB:P57739	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL27RA	IPI	UniProtKB:Q5J5C9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL27RA	IPI	UniProtKB:Q6N075	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL27RA	IPI	UniProtKB:Q6PL45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL27RA	IPI	UniProtKB:Q8N3T1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL27RA	IPI	UniProtKB:Q96EC8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL27RA	IPI	UniProtKB:Q96JW4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL27RA	IPI	UniProtKB:Q96Q80	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Il27ra	IPI	PR:Q8K3I6	Mouse	PMID:12121660
Molecular Function	GO:0005515	protein binding	Il27ra	IPI	PR:O35228	Mouse	PMID:12121660
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Il27ra	IMP	MGI:MGI:3525439	Mouse	PMID:11057672
Biological Process	GO:0002692	negative regulation of cellular extravasation	Il27ra	IGI	UniProtKB:P35951	Mouse	MGI:MGI:5581894|PMID:22927332
Biological Process	GO:0032700	negative regulation of interleukin-17 production	Il27ra	IGI	UniProtKB:P35951	Mouse	MGI:MGI:5581894|PMID:22927332
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Il27ra	IGI	UniProtKB:P35951	Mouse	MGI:MGI:5581894|PMID:22927332
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IL27RA	IMP		Human	PMID:19386761
Biological Process	GO:2000408	negative regulation of T cell extravasation	Il27ra	IGI	UniProtKB:P35951	Mouse	MGI:MGI:5581894|PMID:22927332
Biological Process	GO:2000317	negative regulation of T-helper 17 type immune response	Il27ra	IGI	UniProtKB:P35951	Mouse	MGI:MGI:5581894|PMID:22927332
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Il27ra	IGI	UniProtKB:P35951	Mouse	MGI:MGI:5581894|PMID:22927332
Biological Process	GO:0002829	negative regulation of type 2 immune response	Il27ra	IMP	MGI:MGI:3525439	Mouse	PMID:11057672
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	Il27ra	IMP	MGI:MGI:3525439	Mouse	PMID:11057672
Biological Process	GO:0032729	positive regulation of type II interferon production	Il27ra	IMP	MGI:MGI:3525439	Mouse	PMID:11057672
Biological Process	GO:0048302	regulation of isotype switching to IgG isotypes	Il27ra	IMP	MGI:MGI:3525439	Mouse	PMID:11057672

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern