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Il27ra
Gene Detail
 Symbol
Name
ID
Il27ra
interleukin 27 receptor, alpha
MGI:1355318
Synonyms IL-27R, Tccr, WSX-1
Feature Type protein coding gene
Genetic Map
Chromosome 8
40.26 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:84030287-84042575 bp, - strand
From Ensembl annotation of GRCm38

  12289 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3562  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Il27ra

Human
homologs
Human Homolog IL27RA, interleukin 27 receptor, alpha
NCBI Gene ID 9466
neXtProt AC  NX_Q6UWB1
Human Synonyms  CRL1, IL27R, IL-27RA, TCCR, WSX1, zcytor1
Human Chr (Location)  19p13.11; chr19:14031740-14052919 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
T helper 1 response and responses to parasitic and bacterial infection are altered in homozygous mutant mice.
 
Interactions
Il27ra interacts with 113 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process defense response to Gram-positive bacterium, interleukin-27-mediated signaling pathway, ...
Component integral component of membrane, membrane
Function interleukin-27 receptor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (16)    Tissues (7)   
Theiler Stages: 6, 8, 28
Assay TypeResults
RT-PCR 16
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000005465 (Evidence)
Entrez Gene50931 (Evidence)
UniGene38386
DFCITC1584309, TC1739831
DoTSDT.527056, DT.94176828
NIA Mouse Gene IndexU030021
Consensus CDS ProjectCCDS22465.1
International Mouse Knockout Project StatusIl27ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005465 Ensembl Gene Model | MGI Sequence Detail 12289 C57BL/6J ±  kb
transcript ENSMUST00000005601 Ensembl | MGI Sequence Detail 2657 Not Applicable 
polypeptide ENSMUSP00000005601 Ensembl | MGI Sequence Detail 623 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(7) UniProt(2)
Polymorphisms SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000009002 interleukin-27 receptor subunit alpha
References (Earliest) J:47617 Sprecher CA, et al., Cloning and characterization of a novel class I cytokine receptor. Biochem Biophys Res Commun. 1998 May 8;246(1):82-90
(Latest) J:212012 Bosmann M, et al., Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol. 2014 Jul;96(1):123-31
All references(88)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory