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Il27ra Gene Detail
Summary
  • Symbol
    Il27ra
  • Name
    interleukin 27 receptor, alpha
  • Synonyms
    IL-27R, Tccr, WSX-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355318
    NCBI Gene: 50931
Location & Maps
more
  • Sequence Map
    Chr8:84030287-84042575 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12289 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 40.26 cM, cytoband C3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    IL27RA, interleukin 27 receptor subunit alpha
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL27RA, interleukin 27 receptor subunit alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRL1, IL27R, IL-27RA, TCCR, WSX1, zcytor1
  • Links
    NCBI Gene ID: 9466
    neXtProt AC: NX_Q6UWB1

  • Chr Location
    19p13.11; chr19:14031740-14052919 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotypes from multigenic genotypes
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Il27ra
  • Incidental Mutations
T helper 1 response and responses to parasitic and bacterial infection are altered in homozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005465 Ensembl Gene Model | MGI Sequence Detail 12289 C57BL/6J ±  kb
transcript ENSMUST00000005601 Ensembl | MGI Sequence Detail 2657 Not Applicable  
polypeptide ENSMUSP00000005601 Ensembl | MGI Sequence Detail 623 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    126 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009002 interleukin-27 receptor subunit alpha
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
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  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 92
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 93
  • Earliest
    J:47617 Sprecher CA, et al., Cloning and characterization of a novel class I cytokine receptor. Biochem Biophys Res Commun. 1998 May 8;246(1):82-90
  • Latest
    J:229667 Clemente-Casares X, et al., Expanding antigen-specific regulatory networks to treat autoimmunity. Nature. 2016 Feb 25;530(7591):434-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory