Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL23A
  • Mouse genes Il23a
  • Rat genes Il23a
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il23a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045519	interleukin-23 receptor binding	IL23A	IDA		Human	PMID:11114383
Molecular Function	GO:0045519	interleukin-23 receptor binding	Il23a	IPI	UniProtKB:Q60837	Mouse	MGI:MGI:1927676|PMID:11114383
Molecular Function	GO:0005515	protein binding	IL23A	IPI	UniProtKB:P29460	Human	PMID:11114383
Molecular Function	GO:0005515	protein binding	IL23A	IPI	UniProtKB:P29460	Human	PMID:12023369
Molecular Function	GO:0005515	protein binding	IL23A	IPI	UniProtKB:P29460	Human	PMID:18680750
Molecular Function	GO:0005515	protein binding	IL23A	IPI	UniProtKB:P40855	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IL23A	IPI	UniProtKB:P29460	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	IL23A	IPI	UniProtKB:P40855	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Il23a	IPI	UniProtKB:P29460|UniProtKB:P43432	Mouse	MGI:MGI:1927676|PMID:11114383
Cellular Component	GO:0005615	extracellular space	Il23a	IDA		Mouse	MGI:MGI:6810691|PMID:12417590
Cellular Component	GO:0005615	extracellular space	Il23a	IDA		Mouse	PMID:21148126
Cellular Component	GO:0070743	interleukin-23 complex	IL23A	IDA		Human	PMID:11114383
Cellular Component	GO:0070743	interleukin-23 complex	Il23a	IDA		Mouse	MGI:MGI:1927676|PMID:11114383
Cellular Component	GO:0070743	interleukin-23 complex	Il23a	IPI		Mouse	MGI:MGI:1927676|PMID:11114383
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IL23A	IDA		Human	PMID:15114670
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IL23A	IDA		Human	PMID:20027291
Biological Process	GO:0032693	negative regulation of interleukin-10 production	IL23A	IMP		Human	PMID:16751425
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IL23A	IDA		Human	PMID:11114383
Biological Process	GO:0010536	positive regulation of activation of Janus kinase activity	IL23A	IDA		Human	PMID:12023369
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IL23A	IDA		Human	PMID:12421946
Biological Process	GO:0002230	positive regulation of defense response to virus by host	Il23a	IDA		Mouse	MGI:MGI:3027369|PMID:14688363
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	IL23A	IDA		Human	PMID:20027291
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IL23A	IDA		Human	PMID:15265908
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IL23A	IDA		Human	PMID:20027291
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IL23A	IDA		Human	PMID:16482511
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IL23A	IDA		Human	PMID:16751425
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IL23A	IDA		Human	PMID:17888176
Biological Process	GO:0043382	positive regulation of memory T cell differentiation	Il23a	IDA		Mouse	MGI:MGI:3027369|PMID:14688363
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	IL23A	IDA		Human	PMID:19088061
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	Il23a	IDA		Mouse	MGI:MGI:3841502|PMID:19289819
Biological Process	GO:0051135	positive regulation of NK T cell activation	IL23A	IDA		Human	PMID:19088061
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	IL23A	IDA		Human	PMID:19088061
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IL23A	IDA		Human	PMID:17888176
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	Il23a	IDA		Mouse	MGI:MGI:3027369|PMID:14688363
Biological Process	GO:0042102	positive regulation of T cell proliferation	IL23A	IDA		Human	PMID:12023369
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il23a	IDA		Mouse	MGI:MGI:1927676|PMID:11114383
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	IL23A	IDA		Human	PMID:15114670
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	Il23a	IDA		Mouse	MGI:MGI:3027369|PMID:14688363
Biological Process	GO:2000330	positive regulation of T-helper 17 cell lineage commitment	Il23a	IDA		Mouse	MGI:MGI:3851279|PMID:19501566
Biological Process	GO:2000318	positive regulation of T-helper 17 type immune response	Il23a	IDA		Mouse	MGI:MGI:3851279|PMID:19501566
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il23a	IGI	MGI:MGI:96543	Mouse	PMID:19666510
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il23a	IGI	MGI:MGI:96542	Mouse	PMID:19666510
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IL23A	IMP		Human	PMID:16751425
Biological Process	GO:0032729	positive regulation of type II interferon production	IL23A	IDA		Human	PMID:11114383
Biological Process	GO:0032729	positive regulation of type II interferon production	IL23A	IDA		Human	PMID:17888176
Biological Process	GO:0032729	positive regulation of type II interferon production	IL23A	IDA		Human	PMID:20027291
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IL23A	IDA		Human	PMID:12023369
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IL23A	IDA		Human	PMID:19088061
Biological Process	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	IL23A	IDA		Human	PMID:12023369
Biological Process	GO:0042098	T cell proliferation	Il23a	IDA		Mouse	PMID:16982811

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern