Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL1RAP
  • Mouse genes Il1rap
  • Rat genes Il1rap
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il1rap

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015026	coreceptor activity	IL1RAP	IDA		Human	PMID:10854325
Molecular Function	GO:0004908	interleukin-1 receptor activity	Il1rap	IDA		Mouse	PMID:11880380
Molecular Function	GO:0005149	interleukin-1 receptor binding	Il1rap	IPI	RGD:2892	Rat	PMID:21314939|RGD:5508726
Molecular Function	GO:0002114	interleukin-33 receptor activity	Il1rap	IMP		Mouse	MGI:MGI:4353496|PMID:17675517
Molecular Function	GO:0005515	protein binding	Il1rap	IPI	UniProtKB:Q9QZ06	Mouse	MGI:MGI:1889886|PMID:10854325
Molecular Function	GO:0005515	protein binding	Il1rap	IPI	UniProtKB:P14719	Mouse	MGI:MGI:4353496|PMID:17675517
Molecular Function	GO:0005515	protein binding	Il1rap	IPI	UniProtKB:Q64487	Mouse	MGI:MGI:5645611|PMID:25908590
Molecular Function	GO:0005515	protein binding	Il1rap	IPI	UniProtKB:P14719	Mouse	MGI:MGI:3764000|PMID:18003919
Cellular Component	GO:0005737	cytoplasm	Il1rap	IDA		Rat	PMID:21314939|RGD:5508726
Cellular Component	GO:0098978	glutamatergic synapse	Il1rap	IDA		Mouse	PMID:22357843
Cellular Component	GO:0098978	glutamatergic synapse	Il1rap	IMP		Mouse	PMID:22357843
Cellular Component	GO:0016020	membrane	IL1RAP	HDA		Human	PMID:19946888
Cellular Component	GO:0032991	protein-containing complex	Il1rap	IDA		Rat	PMID:21314939|RGD:5508726
Cellular Component	GO:0045202	synapse	Il1rap	IDA		Mouse	PMID:22357843
Cellular Component	GO:0045202	synapse	Il1rap	IMP		Mouse	PMID:22357843
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Il1rap	IDA		Mouse	PMID:11880380
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IL1RAP	IDA		Human	PMID:9065432
Biological Process	GO:0032623	interleukin-2 production	Il1rap	IDA		Mouse	PMID:11880380
Biological Process	GO:0038172	interleukin-33-mediated signaling pathway	Il1rap	IMP		Mouse	MGI:MGI:4353496|PMID:17675517
Biological Process	GO:0038172	interleukin-33-mediated signaling pathway	Il1rap	IMP		Mouse	MGI:MGI:3764000|PMID:18003919
Biological Process	GO:0032736	positive regulation of interleukin-13 production	Il1rap	IMP		Mouse	MGI:MGI:4353496|PMID:17675517
Biological Process	GO:0032753	positive regulation of interleukin-4 production	Il1rap	IMP		Mouse	MGI:MGI:4353496|PMID:17675517
Biological Process	GO:0032754	positive regulation of interleukin-5 production	Il1rap	IMP		Mouse	MGI:MGI:4353496|PMID:17675517
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Il1rap	IMP		Mouse	MGI:MGI:3764000|PMID:18003919
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Il1rap	IMP		Mouse	MGI:MGI:3764000|PMID:18003919
Biological Process	GO:0051965	positive regulation of synapse assembly	Il1rap	IDA		Mouse	MGI:MGI:5645611|PMID:25908590
Biological Process	GO:0099151	regulation of postsynaptic density assembly	Il1rap	IMP		Mouse	PMID:22357843
Biological Process	GO:0099151	regulation of postsynaptic density assembly	Il1rap	IDA		Mouse	PMID:22357843
Biological Process	GO:1905606	regulation of presynapse assembly	Il1rap	IDA		Mouse	PMID:22357843
Biological Process	GO:1905606	regulation of presynapse assembly	Il1rap	IMP		Mouse	PMID:22357843
Biological Process	GO:0099560	synaptic membrane adhesion	Il1rap	IDA		Mouse	PMID:22357843
Biological Process	GO:0099560	synaptic membrane adhesion	Il1rap	IMP		Mouse	PMID:22357843
Biological Process	GO:0099545	trans-synaptic signaling by trans-synaptic complex	Il1rap	IMP		Mouse	PMID:22357843
Biological Process	GO:0099545	trans-synaptic signaling by trans-synaptic complex	Il1rap	IDA		Mouse	PMID:22357843

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern