Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFNGR1
  • Mouse genes Ifngr1
  • Rat genes Ifngr1
  • Zfish genes ifngr1l,il10ra
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ifngr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004896	cytokine receptor activity	il10ra	IMP	ZFIN:ZDB-MRPHLNO-110928-3	Zfish	PMID:22896613
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:P01579	Human	PMID:11250200
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:P42224	Human	PMID:15780933
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:P01579	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:Q96GQ5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:Q13586	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:Q92581-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:Q96GQ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:Q9NV29	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:Q9NZG7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:P01579	Human	PMID:7617032
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:P42224	Human	PMID:8156998
Molecular Function	GO:0005515	protein binding	IFNGR1	IPI	UniProtKB:P42224	Human	PMID:8662591
Molecular Function	GO:0004906	type II interferon receptor activity	IFNGR1	IDA		Human	PMID:20015550
Cellular Component	GO:0030425	dendrite	Ifngr1	IDA		Rat	PMID:10640190|RGD:1624282
Cellular Component	GO:0005783	endoplasmic reticulum	Ifngr1	IDA		Rat	PMID:10640190|RGD:1624282
Cellular Component	GO:0016020	membrane	IFNGR1	IDA		Human	PMID:28883123
Cellular Component	GO:0005886	plasma membrane	IFNGR1	IDA		Human	PMID:20015550
Cellular Component	GO:0005886	plasma membrane	IFNGR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0014069	postsynaptic density	Ifngr1	IDA		Rat	PMID:10640190|RGD:1624282
Cellular Component	GO:0031982	vesicle	Ifngr1	IDA		Rat	PMID:10640190|RGD:1624282
Biological Process	GO:0048143	astrocyte activation	Ifngr1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:3697769|PMID:17255335
Biological Process	GO:0051607	defense response to virus	Ifngr1	IMP		Mouse	PMID:25268627
Biological Process	GO:0001774	microglial cell activation	Ifngr1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:3697769|PMID:17255335
Biological Process	GO:1900222	negative regulation of amyloid-beta clearance	Ifngr1	IGI	UniProtKB:P01580,UniProtKB:P06804	Mouse	MGI:MGI:3697769|PMID:17255335
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	Ifngr1	IGI	UniProtKB:P01579,UniProtKB:P05067	Mouse	MGI:MGI:3697769|PMID:17255335
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	Ifngr1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:3697769|PMID:17255335
Biological Process	GO:0010628	positive regulation of gene expression	Ifngr1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:3697769|PMID:17255335
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ifngr1	IGI	UniProtKB:P01579	Mouse	MGI:MGI:3697769|PMID:17255335
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	IFNGR1	IDA		Human	PMID:28883123
Biological Process	GO:0038196	type III interferon-mediated signaling pathway	IFNGR1	IDA		Human	PMID:20015550

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern