Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IDUA
  • Mouse genes Idua
  • Rat genes Idua
  • Zfish genes idua
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Idua

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003940	L-iduronidase activity	IDUA	IDA		Human	PMID:24036510
Molecular Function	GO:0003940	L-iduronidase activity	Idua	IDA		Mouse	PMID:7698753
Molecular Function	GO:0003940	L-iduronidase activity	Idua	IMP	MGI:MGI:2651471	Mouse	PMID:15979918
Molecular Function	GO:0003940	L-iduronidase activity	Idua	IMP	MGI:MGI:4415188	Mouse	PMID:19751987
Molecular Function	GO:0003940	L-iduronidase activity	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:19834056
Molecular Function	GO:0003940	L-iduronidase activity	Idua	IDA		Mouse	PMID:19751987
Molecular Function	GO:0003940	L-iduronidase activity	Idua	IMP		Mouse	PMID:21873421
Molecular Function	GO:0003940	L-iduronidase activity	Idua	IDA		Mouse	PMID:16979922
Molecular Function	GO:0003940	L-iduronidase activity	Idua	IDA		Rat	PMID:6138357|RGD:1599427
Molecular Function	GO:0003940	L-iduronidase activity	Idua	IDA		Rat	PMID:8702598|RGD:1625498
Molecular Function	GO:0005102	signaling receptor binding	Idua	IMP		Rat	PMID:6138357|RGD:1599427
Cellular Component	GO:0030135	coated vesicle	Idua	IDA		Rat	PMID:6138357|RGD:1599427
Cellular Component	GO:0070062	extracellular exosome	IDUA	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	Idua	IDA		Mouse	PMID:16979922
Cellular Component	GO:0043202	lysosomal lumen	Idua	IMP	MGI:MGI:2651471	Mouse	PMID:17101178
Cellular Component	GO:0043202	lysosomal lumen	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:9660052
Cellular Component	GO:0005764	lysosome	Idua	IMP	MGI:MGI:4415188	Mouse	PMID:19751987
Cellular Component	GO:0005764	lysosome	Idua	IDA		Rat	PMID:8702598|RGD:1625498
Biological Process	GO:0008344	adult locomotory behavior	Idua	IMP	MGI:MGI:2651471	Mouse	PMID:22580166
Biological Process	GO:0007628	adult walking behavior	Idua	IMP	MGI:MGI:2651471	Mouse	PMID:22580166
Biological Process	GO:0060348	bone development	Idua	IMP	MGI:MGI:4415188	Mouse	PMID:19751987
Biological Process	GO:1990079	cartilage homeostasis	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:19834056
Biological Process	GO:0000902	cell morphogenesis	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:9097952
Biological Process	GO:0048878	chemical homeostasis	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:9097952
Biological Process	GO:0030209	dermatan sulfate catabolic process	IDUA	IDA		Human	PMID:24036510
Biological Process	GO:0030209	dermatan sulfate catabolic process	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:25854773
Biological Process	GO:0030209	dermatan sulfate catabolic process	Idua	IMP	MGI:MGI:4415188	Mouse	PMID:19751987
Biological Process	GO:0030209	dermatan sulfate catabolic process	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:19834056
Biological Process	GO:0030209	dermatan sulfate catabolic process	Idua	IDA		Mouse	PMID:19751987
Biological Process	GO:0030198	extracellular matrix organization	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:25410057
Biological Process	GO:0006027	glycosaminoglycan catabolic process	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:19834056
Biological Process	GO:0006027	glycosaminoglycan catabolic process	Idua	IMP	MGI:MGI:2651471	Mouse	PMID:22580166
Biological Process	GO:0006027	glycosaminoglycan catabolic process	Idua	IMP	MGI:MGI:4415188	Mouse	PMID:19751987
Biological Process	GO:0006027	glycosaminoglycan catabolic process	Idua	IMP	MGI:MGI:2651471	Mouse	PMID:16979922
Biological Process	GO:0006027	glycosaminoglycan catabolic process	Idua	IMP		Mouse	PMID:21873421
Biological Process	GO:0006027	glycosaminoglycan catabolic process	Idua	IDA		Mouse	PMID:16979922
Biological Process	GO:0006027	glycosaminoglycan catabolic process	Idua	IDA		Rat	PMID:6138357|RGD:1599427
Biological Process	GO:0030200	heparan sulfate proteoglycan catabolic process	Idua	IMP	MGI:MGI:2651471	Mouse	PMID:15979918
Biological Process	GO:0030200	heparan sulfate proteoglycan catabolic process	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:25854773
Biological Process	GO:0030211	heparin catabolic process	IDUA	IMP		Human	PMID:21873421
Biological Process	GO:0030211	heparin catabolic process	Idua	IMP	MGI:MGI:4415188	Mouse	PMID:19751987
Biological Process	GO:0030211	heparin catabolic process	Idua	IDA		Mouse	PMID:19751987
Biological Process	GO:0030211	heparin catabolic process	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:19834056
Biological Process	GO:0030211	heparin catabolic process	Idua	IMP		Mouse	PMID:21873421
Biological Process	GO:0035108	limb morphogenesis	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:9097952
Biological Process	GO:0007626	locomotory behavior	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:18022143
Biological Process	GO:0007040	lysosome organization	Idua	IMP	MGI:MGI:4415188	Mouse	PMID:19751987
Biological Process	GO:0007040	lysosome organization	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:9097952
Biological Process	GO:0007613	memory	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:18022143
Biological Process	GO:0061037	negative regulation of cartilage development	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:19834056
Biological Process	GO:0090341	negative regulation of secretion of lysosomal enzymes	Idua	IMP	MGI:MGI:2651471	Mouse	PMID:16979922
Biological Process	GO:0090341	negative regulation of secretion of lysosomal enzymes	Idua	IDA		Mouse	PMID:16979922
Biological Process	GO:0045780	positive regulation of bone resorption	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:19834056
Biological Process	GO:0120158	positive regulation of collagen catabolic process	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:19834056
Biological Process	GO:0048705	skeletal system morphogenesis	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:9097952
Biological Process	GO:0008542	visual learning	Idua	IMP	MGI:MGI:2176236	Mouse	PMID:18022143

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern