Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HVCN1
  • Mouse genes Hvcn1
  • Rat genes Hvcn1
  • Zfish genes hvcn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hvcn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	HVCN1	IPI	UniProtKB:Q96D96	Human	PMID:18509058
Molecular Function	GO:0042802	identical protein binding	Hvcn1	IPI	UniProtKB:Q3U2S8	Mouse	MGI:MGI:6093328|PMID:18583477
Molecular Function	GO:0022843	voltage-gated monoatomic cation channel activity	HVCN1	EXP		Human	PMID:18509058
Molecular Function	GO:0022843	voltage-gated monoatomic cation channel activity	HVCN1	EXP		Human	PMID:19805063
Molecular Function	GO:0030171	voltage-gated proton channel activity	HVCN1	IDA		Human	PMID:16554753
Molecular Function	GO:0030171	voltage-gated proton channel activity	HVCN1	IDA		Human	PMID:22020278
Molecular Function	GO:0030171	voltage-gated proton channel activity	Hvcn1	IDA		Mouse	PMID:16556803
Molecular Function	GO:0030171	voltage-gated proton channel activity	hvcn1	IDA		Zfish	PMID:28774948
Molecular Function	GO:0008270	zinc ion binding	hvcn1	IDA		Zfish	PMID:28774948
Cellular Component	GO:0016324	apical plasma membrane	Hvcn1	IDA		Rat	PMID:24935944|RGD:14985214
Cellular Component	GO:0016020	membrane	HVCN1	IDA		Human	PMID:16554753
Cellular Component	GO:0005886	plasma membrane	HVCN1	IDA		Human	PMID:22020278
Cellular Component	GO:0005886	plasma membrane	hvcn1	IDA		Zfish	PMID:28774948
Biological Process	GO:0071467	cellular response to pH	HVCN1	IDA		Human	PMID:22020278
Biological Process	GO:0071294	cellular response to zinc ion	HVCN1	IDA		Human	PMID:22020278
Biological Process	GO:0032930	positive regulation of superoxide anion generation	Hvcn1	IMP		Rat	PMID:24935944|RGD:14985214
Biological Process	GO:1902600	proton transmembrane transport	HVCN1	IDA		Human	PMID:22020278
Biological Process	GO:1902600	proton transmembrane transport	Hvcn1	IDA		Mouse	PMID:16556803
Biological Process	GO:1902600	proton transmembrane transport	hvcn1	IDA		Zfish	PMID:28774948
Biological Process	GO:0051453	regulation of intracellular pH	Hvcn1	IMP		Rat	PMID:24935944|RGD:14985214
Biological Process	GO:0009268	response to pH	Hvcn1	IDA		Mouse	MGI:MGI:3623706|PMID:16556803
Biological Process	GO:0010043	response to zinc ion	HVCN1	IDA		Human	PMID:16554753
Biological Process	GO:0010043	response to zinc ion	Hvcn1	IDA		Mouse	MGI:MGI:3623706|PMID:16556803
Biological Process	GO:0010043	response to zinc ion	hvcn1	IDA		Zfish	PMID:28774948

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern