Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HOXD8
  • Mouse genes Hoxd8
  • Rat genes Hoxd8
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hoxd8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	HOXD8	IDA		Human	PMID:1756725
Molecular Function	GO:0005515	protein binding	HOXD8	IPI	UniProtKB:O43639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HOXD8	IPI	UniProtKB:Q5SW96	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HOXD8	IPI	UniProtKB:Q9UQB8-6	Human	PMID:32296183
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	HOXD8	IDA		Human	PMID:1756725
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HOXD8	IDA		Human	PMID:28473536
Biological Process	GO:0009952	anterior/posterior pattern specification	Hoxd8	IGI	MGI:MGI:96198	Mouse	PMID:11311170
Biological Process	GO:0009952	anterior/posterior pattern specification	Hoxd8	IMP	MGI:MGI:2151815	Mouse	PMID:11311170
Biological Process	GO:0009952	anterior/posterior pattern specification	Hoxd8	IGI	MGI:MGI:96189	Mouse	PMID:11311170
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hoxd8	IGI	MGI:MGI:96202	Mouse	PMID:1756725
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hoxd8	IGI	MGI:MGI:96210	Mouse	PMID:1756725
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HOXD8	IDA		Human	PMID:1756725
Biological Process	GO:0048705	skeletal system morphogenesis	Hoxd8	IGI	MGI:MGI:96198	Mouse	PMID:11311170
Biological Process	GO:0048705	skeletal system morphogenesis	Hoxd8	IMP	MGI:MGI:2151815	Mouse	PMID:11311170
Biological Process	GO:0048705	skeletal system morphogenesis	Hoxd8	IGI	MGI:MGI:96189	Mouse	PMID:11311170

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern