About   Help   FAQ
Hoxd8
Gene Detail
 Symbol
Name
ID
Member of
Hoxd8
homeobox D8
MGI:96209
Hoxd cluster
Synonyms 4921540P06Rik, Hox-4.3, Hox-5.4
Feature Type protein coding gene
Genetic Map
Chromosome 2
44.13 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:74704615-74707933 bp, + strand
From VEGA annotation of GRCm38

  3319 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10473  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: homeotic protein Hox A7
Gene Tree: Hoxd8

Human
homologs
Human Homolog HOXD8, homeobox D8
NCBI Gene ID 3234
neXtProt AC  NX_P13378
Human Synonyms  HOX4, HOX4E, HOX5.4
Human Chr (Location)  2q31.1; chr2:176129694-176132695 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Targeted(22)
Genomic Mutations involving Hoxd8 (21)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and healthy but show minor and low penetrance homeotic transformations in both lumbar (L1 to T13) and thoracic (T8 to T7) vertebrae.
 
Interactions
Hoxd8 interacts with 208 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process anterior/posterior pattern specification, multicellular organismal development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (329)    Tissues (230)    Images (42)
Theiler Stages: 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 299
Northern blot 3
RT-PCR 27
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(7) cDNA(15) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016550 (Evidence)
Ensembl Gene ModelENSMUSG00000027102 (Evidence)
Entrez Gene15437 (Evidence)
DFCITC1630438, TC1661805, TC1672464
DoTSDT.101344601, DT.97410529
NIA Mouse Gene IndexU001932
Consensus CDS ProjectCCDS16143.1, CCDS71077.1
International Mouse Knockout Project StatusHoxd8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016550 VEGA Gene Model | MGI Sequence Detail 3319 C57BL/6J ±  kb
transcript OTTMUST00000040000 VEGA | MGI Sequence Detail 2634 Not Applicable 
polypeptide OTTMUSP00000017842 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008723 homeobox protein Hox-D8
References (Earliest) J:10602 Duboule D, et al., An update of mouse and human HOX gene nomenclature [letter]. Genomics. 1990 Jul;7(3):458-9
(Latest) J:182758 Tschopp P, et al., Bimodal control of Hoxd gene transcription in the spinal cord defines two regulatory subclusters. Development. 2012 Mar;139(5):929-39
All references(55)
Other
accession IDs
MGD-MRK-10850, MGD-MRK-10910, MGI:1913985, MGI:2138833

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory