About   Help   FAQ
Hoxd8 Gene Detail
Summary
  • Symbol
    Hoxd8
  • Name
    homeobox D8
  • Synonyms
    4921540P06Rik, Hox-4.3, Hox-5.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96209
    NCBI Gene: 15437
  • Member of
    Hoxd cluster
  • Gene Overview
    MyGene.info: HOXD8
Location & Maps
more
  • Sequence Map
    Chr2:74704615-74707933 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3319 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.13 cM, cytoband D
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    HOXD8, homeobox D8
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HOXD8, homeobox D8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX4, HOX4E, HOX5.4
  • Links
    NCBI Gene ID: 3234
    neXtProt AC: NX_P13378

  • Chr Location
    2q31.1; chr2:176129694-176132695 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    28
  • Genomic Mutations
    30 involving Hoxd8
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable and healthy but show minor and low penetrance homeotic transformations in both lumbar (L1 to T13) and thoracic (T8 to T7) vertebrae.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016550 VEGA Gene Model | MGI Sequence Detail 3319 C57BL/6J ±  kb
transcript OTTMUST00000040000 VEGA | MGI Sequence Detail 2634 Not Applicable  
polypeptide OTTMUSP00000017842 VEGA | MGI Sequence Detail 289 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    7 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 7
    cDNA 15
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10850, MGD-MRK-10910, MGI:1913985, MGI:2138833
References
more
  • Summaries
    All 57
    Developmental Gene Expression 27
    Gene Ontology 5
    Phenotypes 39
  • Earliest
    J:10602 Duboule D, et al., An update of mouse and human HOX gene nomenclature [letter]. Genomics. 1990 Jul;7(3):458-9
  • Latest
    J:231885 Beccari L, et al., A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus. Genes Dev. 2016 May 15;30(10):1172-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory