Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HLF
  • Mouse genes Hlf
  • Rat genes Hlf
  • Zfish genes hlfa,hlfb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hlf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	HLF	IDA		Human	PMID:8065331
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	HLF	IMP		Human	PMID:8065331
Molecular Function	GO:0005515	protein binding	HLF	IPI	UniProtKB:P35638	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	HLF	IPI	UniProtKB:Q16520	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	HLF	IPI	UniProtKB:Q9NR55	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	HLF	IPI	UniProtKB:Q10586	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	HLF	IPI	UniProtKB:P35638	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	HLF	IPI	UniProtKB:Q10586	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	HLF	IPI	UniProtKB:Q16520	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	HLF	IPI	UniProtKB:Q9NR55	Human	PMID:23661758
Molecular Function	GO:0043565	sequence-specific DNA binding	HLF	IMP		Human	PMID:8065331
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HLF	IDA		Human	PMID:28473536
Cellular Component	GO:0005654	nucleoplasm	HLF	IDA		Human	GO_REF:0000052
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	HLF	IPI		Human	PMID:23661758
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HLF	IDA		Human	PMID:8065331
Biological Process	GO:0035914	skeletal muscle cell differentiation	Hlf	IMP		Mouse	PMID:22147266

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern