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Hlf
Gene Detail
Symbol

Name
ID
Hlf
hepatic leukemia factor
MGI:96108
Synonyms
E230015K02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
55.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:90336536-90390895 bp, - strand
From VEGA annotation of GRCm38

  54360 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31074  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HLF
Gene Tree: Hlf

Human
homologs
HLF, hepatic leukemia factor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3131
neXtProt AC: NX_Q16534

Human Chr (Location): 17q22; chr17:55264960-55325065 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Hlf (3)
Incidental mutations (data from Mutagenetix , APF )
Mutations Annotated to Human Diseases (1)   
Interactions
Hlf interacts with 416 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process regulation of transcription, DNA-templated, rhythmic process, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (92)    Tissues (92)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 92
cDNA source data(61)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HLF ; Xenbase hlf ; ZFIN hlfa, hlfb    NEW 
Molecular
reagents
All nucleic(62) cDNA(61) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000001287 (Evidence)
Ensembl Gene Model ENSMUSG00000003949 (Evidence)
Entrez Gene 217082 (Evidence)
UniGene 158903
DFCI TC1577248, TC1695222
DoTS DT.101283267, DT.101370948, DT.101725108, DT.87027121
NIA Mouse Gene Index U033262
Consensus CDS Project CCDS25241.1
International Mouse Phenotyping Consortium Status Hlf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001287 VEGA Gene Model | MGI Sequence Detail 54360 C57BL/6J ±  kb
transcript OTTMUST00000002563 VEGA | MGI Sequence Detail 5642 Not Applicable 
polypeptide OTTMUSP00000001268 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(374 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
Protein Ontology PR:000008618 hepatic leukemia factor
References
(Earliest) J:18114 Inaba T, et al., Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science. 1992 Jul 24;257(5069):531-4
(Latest) J:178918 Rajan S, et al., Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol Genomics. 2011 Dec 6;
All references(38)
Other
accession IDs
MGD-MRK-10742, MGI:2444586

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory