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Hlf
Gene Detail
Symbol

Name
ID
Hlf
hepatic leukemia factor
MGI:96108
Synonyms
E230015K02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
55.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:90336536-90390895 bp, - strand
From VEGA annotation of GRCm38

  54360 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31074  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hlf

Human
homologs
Human Homolog HLF, hepatic leukemia factor
NCBI Gene ID 3131
neXtProt AC  NX_Q16534
Human Chr (Location)  17q22; chr17:55264960-55325065 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Hlf (2)
Incidental mutations (data from Mutagenetix , APF )
Alleles Annotated to Human Diseases(1)   
Interactions
Hlf interacts with 417 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process regulation of transcription, DNA-templated, rhythmic process, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (92)    Tissues (92)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 92
cDNA source data(61)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(62) cDNA(61) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001287 (Evidence)
Ensembl Gene ModelENSMUSG00000003949 (Evidence)
Entrez Gene217082 (Evidence)
UniGene158903
DFCITC1577248, TC1695222
DoTSDT.101283267, DT.101370948, DT.101725108, DT.87027121
NIA Mouse Gene IndexU033262
Consensus CDS ProjectCCDS25241.1
International Mouse Knockout Project StatusHlf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001287 VEGA Gene Model | MGI Sequence Detail 54360 C57BL/6J ±  kb
transcript OTTMUST00000002563 VEGA | MGI Sequence Detail 5642 Not Applicable 
polypeptide OTTMUSP00000001268 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(374 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
Protein Ontology PR:000008618 hepatic leukemia factor
References
(Earliest) J:18114 Inaba T, et al., Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science. 1992 Jul 24;257(5069):531-4
(Latest) J:178918 Rajan S, et al., Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol Genomics. 2011 Dec 6;
All references(39)
Other
accession IDs
MGD-MRK-10742, MGI:2444586

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory