Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HEXIM1
  • Mouse genes Hexim1
  • Rat genes Hexim1
  • Zfish genes hexim1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hexim1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097322	7SK snRNA binding	HEXIM1	IDA		Human	PMID:12832472
Molecular Function	GO:0097322	7SK snRNA binding	HEXIM1	IDA		Human	PMID:18249148
Molecular Function	GO:0097322	7SK snRNA binding	HEXIM1	IDA		Human	PMID:18483487
Molecular Function	GO:0097322	7SK snRNA binding	HEXIM1	IDA		Human	PMID:19883659
Molecular Function	GO:0097322	7SK snRNA binding	HEXIM1	IDA		Human	PMID:28431135
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	HEXIM1	IDA		Human	PMID:14580347
Molecular Function	GO:0042802	identical protein binding	HEXIM1	IPI	UniProtKB:O94992	Human	PMID:17724342
Molecular Function	GO:0042802	identical protein binding	HEXIM1	IPI	UniProtKB:O94992	Human	PMID:31515488
Molecular Function	GO:0106140	P-TEFb complex binding	HEXIM1	IDA		Human	PMID:18249148
Molecular Function	GO:0106140	P-TEFb complex binding	HEXIM1	IDA		Human	PMID:18483487
Molecular Function	GO:0106140	P-TEFb complex binding	HEXIM1	IDA		Human	PMID:28431135
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:O60563|UniProtKB:P50750	Human	PMID:12832472
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P50750	Human	PMID:14580347
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:Q96MH2	Human	PMID:15713661
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P04150	Human	PMID:15941832
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:O60563	Human	PMID:17724342
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:O60563	Human	PMID:18281698
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:Q4G0J3	Human	PMID:18281698
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:O60563	Human	PMID:18483487
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P50750	Human	PMID:18483487
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:Q4G0J3	Human	PMID:18483487
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:O60563	Human	PMID:19387490
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:O60563	Human	PMID:19883659
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:O60563|UniProtKB:P52292	Human	PMID:19883659
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:O60583-2	Human	PMID:19883659
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P52292	Human	PMID:19883659
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P50750	Human	PMID:20562857
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:Q15554	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P50750	Human	PMID:21533037
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P50750	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P50750	Human	PMID:24360279
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P50750	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P50750	Human	PMID:25470060
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:Q4G0J3	Human	PMID:25470060
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:O60563	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:Q4G0J3	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:Q96MH2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P24928,UniProtKB:P50750	Human	PMID:30824372
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P50750,UniProtKB:Q4G0J3,UniProtKB:Q7L2J0	Human	PMID:30824372
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P50750,UniProtKB:Q4G0J3,UniProtKB:Q9Y580	Human	PMID:30824372
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:Q96MH2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEXIM1	IPI	UniProtKB:P50750	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Hexim1	IPI	UniProtKB:Q62093|UniProtKB:Q6PDM2	Mouse	MGI:MGI:5553217|PMID:23663783
Molecular Function	GO:0004860	protein kinase inhibitor activity	HEXIM1	IDA		Human	PMID:28431135
Molecular Function	GO:0017069	snRNA binding	HEXIM1	IDA		Human	PMID:14580347
Cellular Component	GO:0120259	7SK snRNP	HEXIM1	IDA		Human	PMID:18249148
Cellular Component	GO:0120259	7SK snRNP	HEXIM1	IDA		Human	PMID:18483487
Cellular Component	GO:0120259	7SK snRNP	HEXIM1	IDA		Human	PMID:28431135
Cellular Component	GO:0005737	cytoplasm	HEXIM1	IDA		Human	PMID:12581153
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	HEXIM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	HEXIM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	HEXIM1	IDA		Human	PMID:12581153
Cellular Component	GO:0005634	nucleus	HEXIM1	IDA		Human	PMID:28712728
Cellular Component	GO:0005634	nucleus	Hexim1	IDA		Mouse	PMID:12119119
Biological Process	GO:0002218	activation of innate immune response	HEXIM1	IDA		Human	PMID:28712728
Biological Process	GO:0007507	heart development	Hexim1	IMP	MGI:MGI:3052225	Mouse	PMID:15172687
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	HEXIM1	IDA		Human	PMID:14580347
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HEXIM1	IDA		Human	PMID:14580347
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hexim1	IDA		Mouse	PMID:12119119
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HEXIM1	IDA		Human	PMID:14580347
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HEXIM1	IMP		Human	PMID:18483487
Biological Process	GO:0032897	negative regulation of viral transcription	HEXIM1	IMP		Human	PMID:18249148
Biological Process	GO:1901798	positive regulation of signal transduction by p53 class mediator	HEXIM1	IMP		Human	PMID:22948151
Biological Process	GO:0065003	protein-containing complex assembly	hexim1	IPI	ZFIN:ZDB-GENE-030131-321,ZFIN:ZDB-GENE-030131-4637,ZFIN:ZDB-GENE-030131-6397	Zfish	PMID:31183407

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern