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Hexim1 Gene Detail
Summary
  • Symbol
    Hexim1
  • Name
    hexamethylene bis-acetamide inducible 1
  • Synonyms
    7330426E13Rik, Clp1, CLP-1, HIS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385923
    NCBI Gene: 192231
  • Gene Overview
    MyGene.info: HEXIM1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:103116325-103119725 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 66.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385923
protein coding gene Chr11:103116231-103119725 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019256
protein coding gene Chr11:106152522-106155652 (+)
A/J MGP_AJ_G0019224
protein coding gene Chr11:101658760-101661936 (+)
AKR/J MGP_AKRJ_G0019193
protein coding gene Chr11:104793354-104796848 (+)
BALB/cJ MGP_BALBcJ_G0019198
protein coding gene Chr11:102129998-102133842 (+)
C3H/HeJ MGP_C3HHeJ_G0019007
protein coding gene Chr11:105018857-105022078 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019647
protein coding gene Chr11:109465783-109471517 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017273
protein coding gene Chr11:99074855-99078334 (+)
CAST/EiJ MGP_CASTEiJ_G0018561
protein coding gene Chr11:106032410-106036420 (+)
CBA/J MGP_CBAJ_G0018976
protein coding gene Chr11:114012766-114018331 (+)
DBA/2J MGP_DBA2J_G0019088
protein coding gene Chr11:101170197-101174115 (+)
FVB/NJ MGP_FVBNJ_G0019078
protein coding gene Chr11:100712253-100715741 (+)
LP/J MGP_LPJ_G0019157
protein coding gene Chr11:106673760-106679033 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019109
protein coding gene Chr11:113401805-113405532 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019685
protein coding gene Chr11:105179710-105184029 (+)
PWK/PhJ MGP_PWKPhJ_G0018324
protein coding gene Chr11:102238776-102242192 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018116
protein coding gene Chr11:104933831-104938107 (+)
WSB/EiJ MGP_WSBEiJ_G0018610
protein coding gene Chr11:105176981-105180693 (+)



Homology
more
  • Human Ortholog
    HEXIM1, hexamethylene bisacetamide inducible 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HEXIM1, hexamethylene bisacetamide inducible 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLP1, EDG1, HIS1, MAQ1
  • Links
    NCBI Gene ID: 10614
    neXtProt AC: NX_O94992
    UniProt: O94992

  • Chr Location
    17q21.31; chr17:45147317-45152101 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit prenatal lethalilty associated with dilated cardiomyopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 192231 NCBI Gene Model | MGI Sequence Detail 3401 C57BL/6J ±  kb
    transcript NM_138753 RefSeq | MGI Sequence Detail 3401 Not Specified  
    polypeptide Q8R409 UniProt | EBI | MGI Sequence Detail 356 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 95
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925754
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:257846 Bazi Z, et al., Rn7SK small nuclear RNA is involved in neuronal differentiation. J Cell Biochem. 2018 Apr;119(4):3174-3182

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory