Hexim1 MGI Mouse Gene Detail - MGI:2385923 - hexamethylene bis-acetamide inducible 1

Symbol

Hexim1
Name

hexamethylene bis-acetamide inducible 1
Synonyms

7330426E13Rik, Clp1, CLP-1, HIS1

Feature Type

protein coding gene
IDs

MGI:2385923
NCBI Gene: 192231
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:103007151-103010551 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 66.71 cM
Mapping Data

2 experiments

SNPs within 2kb

84 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385923	protein coding gene	Chr11:103007057-103010551 (+)
129S1/SvImJ	ENSMUSG00200049070	protein coding gene	Chr11:100292455-100295949 (+)
A/J	ENSMUSG00195052077	protein coding gene	Chr11:99992511-99996007 (+)
AKR/J	ENSMUSG00220048390	protein coding gene	Chr11:100200357-100203851 (+)
BALB/cJ	ENSMUSG00180050929	protein coding gene	Chr11:100338842-100342336 (+)
C3H/HeJ	ENSMUSG00175049812	protein coding gene	Chr11:100266047-100269541 (+)
C57BL/6NJ	ENSMUSG00215052408	protein coding gene	Chr11:99829144-99832638 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017273	protein coding gene	Chr11:99074855-99078334 (+)
CAST/EiJ	ENSTCUG00005050542	protein coding gene	Chr11:99760176-99763669 (+)
CBA/J	ENSMUSG00210053281	protein coding gene	Chr11:99968317-99971813 (+)
DBA/2J	ENSMUSG00185047204	protein coding gene	Chr11:100315866-100319360 (+)
FVB/NJ	ENSMUSG00205047696	protein coding gene	Chr11:100150881-100154373 (+)
JF1/MsJ	ENSUMUG00000050475	protein coding gene	Chr11:100568538-100572039 (+)
LP/J	ENSMUSG00230030880	protein coding gene	Chr11:101368296-101371790 (+)
NOD/ShiLtJ	ENSMUSG00190043317	protein coding gene	Chr11:100347071-100350565 (+)
NZO/HlLtJ	ENSMUSG00225049083	protein coding gene	Chr11:103383441-103386935 (+)
PWK/PhJ	ENSLUMG00010044826	protein coding gene	Chr11:100097986-100101480 (+)
SPRET/EiJ	ENSMSPG00010048746	protein coding gene	Chr11:100595617-100599102 (+)
WSB/EiJ	ENSIUOG00005049691	protein coding gene	Chr11:100104210-100107704 (+)

Human Ortholog

HEXIM1, HEXIM P-TEFb complex subunit 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HEXIM1, HEXIM P-TEFb complex subunit 1
Synonyms

EDG1, HIS1, MAQ1
Links

HGNC:24953

NCBI Gene ID: 10614

UniProt: O94992
Chr Location

17q21.31; chr17:45148475-45152099 (+) GRCh38

MGI Vertebrate Homology

Hexim1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HEXIM1
Gene Tree

Hexim1

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Gene trapped

2
Targeted

3
Genomic Mutations

1 involving Hexim1
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit prenatal lethalilty associated with dilated cardiomyopathy.

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All GO Annotations

56
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

69
cDNA Data

94
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hexim1

ZFIN hexim1

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS25513.1

Ensembl

ENSMUSG00000048878 (Evidence)
NCBI Gene

192231

			Length	Strain/Species	Flank
genomic	192231	NCBI Gene Model \| MGI Sequence Detail	3401	C57BL/6J	± kb
transcript	NM_138753	RefSeq \| MGI Sequence Detail	3401	Not Specified
polypeptide	Q8R409	UniProt \| EBI \| MGI Sequence Detail	356	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008526 protein HEXIM1

(term hierarchy)
InterPro Domains

IPR024872 HEXIM
GlyGen

Q8R409 1 site, 1 O-linked glycan (1 site)

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All nucleic 98

cDNA 95

Primer pair 2

Other 1

Antibodies 6

Microarray probesets 5

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MGI:1925754

Summaries

All 65

Developmental Gene Expression 10

Gene Ontology 9

Phenotypes 21
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:388209 Fang Y, et al., Enhanced P-TEFb activity compromises dentate gyrus neurogenesis in mice. EMBO J. 2026 May;45(9):3102-3123

TSS for Hexim1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105310	Chr11:103007054-103007061 (+)	-93 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24