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Hexim1
Gene Detail
 Symbol
Name
ID
Hexim1
hexamethylene bis-acetamide inducible 1
MGI:2385923
Synonyms 7330426E13Rik, Clp1, CLP-1, HIS1
Feature Type protein coding gene
Genetic Map
Chromosome 11
66.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:103116231-103119725 bp, + strand
From VEGA annotation of GRCm38

  3495 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31382  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Hexim1

Human
homologs
Human Homolog HEXIM1, hexamethylene bis-acetamide inducible 1
NCBI Gene ID 10614
neXtProt AC  NX_O94992
Human Synonyms  CLP1, EDG1, HIS1, MAQ1
Human Chr (Location)  17q21.31; chr17:45147317-45152101 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
 
Mice homozygous for a gene trapped allele exhibit prenatal lethalilty associated with dilated cardiomyopathy.
 
Interactions
Hexim1 interacts with 281 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process heart development, negative regulation of cyclin-dependent protein serine/threonine kinase activity, ...
Component cytoplasm, nucleus
Function cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (25)    Tissues (16)    Images (2)
Theiler Stages: 19, 23
Assay TypeResults
RNA in situ 25
cDNA source data(93)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) cDNA(94)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003296 (Evidence)
Ensembl Gene ModelENSMUSG00000048878 (Evidence)
Entrez Gene192231 (Evidence)
UniGene8763
DFCITC1575781
DoTSDT.101373950, DT.531975
NIA Mouse Gene IndexU013411
Consensus CDS ProjectCCDS25513.1
International Mouse Knockout Project StatusHexim1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003296 VEGA Gene Model | MGI Sequence Detail 3495 C57BL/6J ±  kb
transcript OTTMUST00000006882 VEGA | MGI Sequence Detail 3495 Not Applicable 
polypeptide OTTMUSP00000003286 VEGA | MGI Sequence Detail 356 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024872 HEXIM
Protein Ontology PR:000008526 protein HEXIM1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206891 Ji X, et al., SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell. 2013 May 9;153(4):855-68
All references(44)
Other
accession IDs
MGI:1925754

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory