Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HES3
  • Mouse genes Hes3
  • Rat genes Hes3
  • Zfish genes her3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hes3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	her3	IDA		Zfish	PMID:15169758
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hes3	IMP		Mouse	MGI:MGI:1928504|PMID:10858455
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hes3	IDA		Mouse	MGI:MGI:1928504|PMID:10858455
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Hes3	IMP		Mouse	MGI:MGI:1928504|PMID:10858455
Biological Process	GO:0021575	hindbrain morphogenesis	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:11500373
Biological Process	GO:0001701	in utero embryonic development	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:11500373
Biological Process	GO:0030901	midbrain development	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:11500373
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:11522634
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hes3	IDA		Rat	PMID:1340473|RGD:61625
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	her3	IDA		Zfish	PMID:15169758
Biological Process	GO:0050768	negative regulation of neurogenesis	her3	IMP	ZFIN:ZDB-MRPHLNO-050503-3	Zfish	PMID:15716337
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes3	IDA		Mouse	MGI:MGI:1928504|PMID:10858455
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:19050759
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes3	IGI	MGI:MGI:104876	Mouse	PMID:19050759
Biological Process	GO:0021915	neural tube development	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:11500373
Biological Process	GO:0021557	oculomotor nerve development	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:11500373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:11500373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:19050759
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hes3	IGI	MGI:MGI:104876	Mouse	PMID:19050759
Biological Process	GO:0050767	regulation of neurogenesis	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:19050759
Biological Process	GO:0050767	regulation of neurogenesis	Hes3	IGI	MGI:MGI:104876	Mouse	PMID:19050759
Biological Process	GO:0060164	regulation of timing of neuron differentiation	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:11500373
Biological Process	GO:0006366	transcription by RNA polymerase II	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:19050759
Biological Process	GO:0006366	transcription by RNA polymerase II	Hes3	IGI	MGI:MGI:104876	Mouse	PMID:19050759
Biological Process	GO:0021558	trochlear nerve development	Hes3	IGI	MGI:MGI:104853	Mouse	PMID:11500373

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern