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Hes3 Gene Detail
Summary
  • Symbol
    Hes3
  • Name
    hairy and enhancer of split 3 (Drosophila)
  • Synonyms
    bHLHb43
  • Feature Type
    protein coding gene
  • IDs
    MGI:104877
    NCBI Gene: 15207
  • Gene Overview
    MyGene.info: HES3
Location & Maps
more
  • Sequence Map
    Chr4:152285972-152291662 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5691 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 83.01 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HES3, hes family bHLH transcription factor 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HES3, hes family bHLH transcription factor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHb43
  • Links
    NCBI Gene ID: 390992
    neXtProt AC: NX_Q5TGS1

  • Chr Location
    1p36.31; chr1:6244158-6245578 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    15 phenotype references
  • All Mutations and Alleles
    7
  • Gene trapped
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Hes3
  • Incidental Mutations
    APF
Homozygous null mice are fertile and display no obvious abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010409 VEGA Gene Model | MGI Sequence Detail 5691 C57BL/6J ±  kb
transcript OTTMUST00000024267 VEGA | MGI Sequence Detail 1829 Not Applicable  
polypeptide OTTMUSP00000011161 VEGA | MGI Sequence Detail 175 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    23 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008517 transcription factor HES-3
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR003650 Orange domain
Molecular
Reagents
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  • All nucleic 20
    Genomic 1
    cDNA 15
    Primer pair 3
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-28177
References
more
  • Summaries
    All 59
    Developmental Gene Expression 29
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:43728 Sasai Y, et al., Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 1992 Dec;6(12B):2620-34
  • Latest
    J:214666 Brunskill EW, et al., A gene expression atlas of early craniofacial development. Dev Biol. 2014 Jul 15;391(2):133-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory