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Hes3 Gene Detail
Summary
  • Symbol
    Hes3
  • Name
    hes family bHLH transcription factor 3
  • Synonyms
    bHLHb43
  • Feature Type
    protein coding gene
  • IDs
    MGI:104877
    NCBI Gene: 15207
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:152370429-152376119 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 83.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104877
 protein coding gene Chr4:152369707-152376133 (-)
129S1/SvImJ ENSMUSG00200018435
 protein coding gene Chr4:143436861-143442703 (-)
A/J ENSMUSG00195015389
 protein coding gene Chr4:145071907-145078379 (-)
AKR/J ENSMUSG00220024262
 protein coding gene Chr4:144658436-144664908 (-)
BALB/cJ ENSMUSG00180002303
 protein coding gene Chr4:142754084-142760570 (-)
C3H/HeJ ENSMUSG00175017083
 protein coding gene Chr4:146038978-146045464 (-)
C57BL/6NJ ENSMUSG00215017795
 protein coding gene Chr4:144882553-144889039 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026853
 protein coding gene Chr4:142186215-142187387 (-)
CAST/EiJ ENSTCUG00005028118
 protein coding gene Chr4:148758558-148764272 (-)
CBA/J ENSMUSG00210005569
 protein coding gene Chr4:144690620-144697106 (-)
DBA/2J ENSMUSG00185014867
 protein coding gene Chr4:148255554-148262026 (-)
FVB/NJ ENSMUSG00205011314
 protein coding gene Chr4:143152145-143158617 (-)
JF1/MsJ ENSUMUG00000005384
 protein coding gene Chr4:151283943-151289658 (-)
LP/J ENSMUSG00230024155
 protein coding gene Chr4:154988698-154995184 (-)
NOD/ShiLtJ ENSMUSG00190003383
 protein coding gene Chr4:144354773-144361259 (-)
NZO/HlLtJ ENSMUSG00225023011
 protein coding gene Chr4:158982156-158988628 (-)
PWK/PhJ ENSLUMG00010026531
 protein coding gene Chr4:143552951-143558791 (-)
SPRET/EiJ ENSMSPG00010023887
 protein coding gene Chr4:145489517-145491368 (-)
WSB/EiJ ENSIUOG00005006156
 protein coding gene Chr4:142565229-142571071 (-)



Homology
more
  • Human Ortholog
    HES3, hes family bHLH transcription factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HES3, hes family bHLH transcription factor 3
  • Synonyms
    bHLHb43
  • Links
    NCBI Gene ID: 390992
    UniProt: Q5TGS1

  • Chr Location
    1p36.31; chr1:6244179-6245578 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    20 phenotype references
Homozygous null mice are fertile and display no obvious abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1014
  • Tissues
    294
  • cDNA Data
    10
  • Literature Summary
    33
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028946 Ensembl Gene Model | MGI Sequence Detail 5691 C57BL/6J ±  kb
transcript ENSMUST00000218045 Ensembl | MGI Sequence Detail 962 Not Applicable  
polypeptide ENSMUSP00000151815 Ensembl | MGI Sequence Detail 200 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    Genomic 1
    cDNA 18
    Primer pair 4
    Other 6

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-28177
References
more
  • Summaries
    All 73
    Developmental Gene Expression 33
    Gene Ontology 9
    Phenotypes 20
  • Earliest
    J:43728 Sasai Y, et al., Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 1992 Dec;6(12B):2620-34
  • Latest
    J:341148 Bosze B, et al., Notch pathway mutants do not equivalently perturb mouse embryonic retinal development. PLoS Genet. 2023 Sep;19(9):e1010928
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory