Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HARS2
  • Mouse genes Hars2
  • Rat genes Hars2
  • Zfish genes hars
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hars2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004821	histidine-tRNA ligase activity	HARS2	IDA		Human	PMID:21464306
Molecular Function	GO:0042802	identical protein binding	HARS2	IPI	UniProtKB:P49590	Human	PMID:21464306
Molecular Function	GO:0005515	protein binding	HARS2	IPI	UniProtKB:Q6RW13	Human	PMID:25416956
Molecular Function	GO:0003723	RNA binding	HARS2	HDA		Human	PMID:22681889
Cellular Component	GO:0005737	cytoplasm	hars	IDA		Zfish	PMID:28934368|ZFIN:ZDB-PUB-170922-6
Cellular Component	GO:0005737	cytoplasm	hars	IDA		Zfish	PMID:28934368
Cellular Component	GO:0005739	mitochondrion	HARS2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	HARS2	IDA		Human	PMID:21464306
Cellular Component	GO:0005739	mitochondrion	Hars2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	hars	IDA		Zfish	PMID:28934368|ZFIN:ZDB-PUB-170922-6
Cellular Component	GO:0005739	mitochondrion	hars	IDA		Zfish	PMID:28934368
Biological Process	GO:0006427	histidyl-tRNA aminoacylation	HARS2	IDA		Human	PMID:21464306
Biological Process	GO:1901342	regulation of vasculature development	hars	IGI	ZFIN:ZDB-GENO-180920-25,ZFIN:ZDB-MRPHLNO-070810-2	Zfish	PMID:29744287
Biological Process	GO:1901342	regulation of vasculature development	hars	IMP	ZFIN:ZDB-GENO-180920-25	Zfish	PMID:29744287
Biological Process	GO:0002040	sprouting angiogenesis	hars	IMP	ZFIN:ZDB-GENO-180920-25	Zfish	PMID:29744287

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern