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Hars2
Gene Detail
Symbol

Name
ID
Hars2
histidyl-tRNA synthetase 2, mitochondrial (putative)
MGI:1918041
Synonyms
4631412B19Rik, Harsl, HARSR, HO3
Feature Type
protein coding gene
Genetic Map
Chromosome 18
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:36783008-36792562 bp, + strand
From VEGA annotation of GRCm38

  9555 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40819  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: HARS2
Protein SuperFamily: histidyl-tRNA synthetase
Gene Tree: Hars2

Human
homologs
HARS2, histidyl-tRNA synthetase 2, mitochondrial
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23438
neXtProt AC: NX_P49590

Human Synonyms: HARSL, HARSR, HO3, PRLTS2

Human Chr (Location): 5q31.3; chr5:140691426-140699318 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HARS2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hars2 interacts with 225 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process histidyl-tRNA aminoacylation, translation, ...
Component cytoplasm, mitochondrion
Function aminoacyl-tRNA ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (96)    Tissues (96)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 96
cDNA source data(56)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100488813    NEW 
Molecular
reagents
All nucleic(56) cDNA(56)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000033867 (Evidence)
Ensembl Gene Model ENSMUSG00000019143 (Evidence)
Entrez Gene 70791 (Evidence)
UniGene 282700
DFCI TC1577372, TC1649981
DoTS DT.99852407, DT.91292827, DT.533074
NIA Mouse Gene Index U018596
EC 6.1.1.21
Consensus CDS Project CCDS29165.1
International Mouse Phenotyping Consortium Status Hars2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033867 VEGA Gene Model | MGI Sequence Detail 9555 C57BL/6J ±  kb
transcript OTTMUST00000085354 VEGA | MGI Sequence Detail 3336 Not Applicable 
polypeptide OTTMUSP00000046108 VEGA | MGI Sequence Detail 505 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(13) UniProt(3)
Polymorphisms
SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006195 Aminoacyl-tRNA synthetase, class II
InterPro IPR004154 Anticodon-binding
InterPro IPR015807 Histidine-tRNA ligase
InterPro IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit
Protein Ontology PR:000029775 histidine--tRNA ligase, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(33)
Other
accession IDs
MGI:2147244

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory