Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HLA-DQB1,HLA-DQB2
  • Mouse genes H2-Ab1
  • Rat genes RT1-B,RT1-Bb
  • Zfish genes mhc2bl,mhc2d4b,mhc2d8.35b2,mhc2d8.37b2,mhc2d8.45b1,mhc2dab,mhc2dbb,mhc2dgb,mhc2dhb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H2-Ab1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042605	peptide antigen binding	H2-Ab1	IDA		Mouse	PMID:9432982
Molecular Function	GO:0042605	peptide antigen binding	H2-Ab1	IDA		Mouse	PMID:11069069
Molecular Function	GO:1990405	protein antigen binding	H2-Ab1	IPI	UniProtKB:P0A0L2	Mouse	MGI:MGI:4942275|PMID:2159298
Molecular Function	GO:0005515	protein binding	HLA-DQB1	IPI	UniProtKB:P01909	Human	PMID:14769912
Molecular Function	GO:0005515	protein binding	HLA-DQB1	IPI	UniProtKB:P01909	Human	PMID:17629515
Molecular Function	GO:0005515	protein binding	HLA-DQB1	IPI	UniProtKB:P01909	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	H2-Ab1	IPI	PR:P14434	Mouse	PMID:7985028
Molecular Function	GO:0005515	protein binding	H2-Ab1	IPI	PR:P04441	Mouse	PMID:7985028
Molecular Function	GO:0044877	protein-containing complex binding	RT1-Bb	IDA		Rat	PMID:2465490|RGD:5147667
Molecular Function	GO:0015643	toxic substance binding	H2-Ab1	IPI	UniProtKB:P0A0L2	Mouse	MGI:MGI:4942275|PMID:2159298
Molecular Function	GO:0031625	ubiquitin protein ligase binding	H2-Ab1	IPI	UniProtKB:Q9DBD2	Mouse	MGI:MGI:3785681|PMID:16785530
Cellular Component	GO:0009986	cell surface	RT1-Bb	IDA		Rat	PMID:12034349|RGD:5147665
Cellular Component	GO:0005769	early endosome	H2-Ab1	IDA		Mouse	PMID:11854359
Cellular Component	GO:0009897	external side of plasma membrane	H2-Ab1	IDA		Mouse	PMID:7679955
Cellular Component	GO:0009897	external side of plasma membrane	H2-Ab1	IDA		Mouse	PMID:8638109
Cellular Component	GO:0009897	external side of plasma membrane	H2-Ab1	IDA		Mouse	PMID:9432982
Cellular Component	GO:0009897	external side of plasma membrane	H2-Ab1	IDA		Mouse	PMID:8598041
Cellular Component	GO:0009897	external side of plasma membrane	H2-Ab1	IDA		Mouse	PMID:9492004
Cellular Component	GO:0009897	external side of plasma membrane	H2-Ab1	IDA		Mouse	PMID:8598040
Cellular Component	GO:0009897	external side of plasma membrane	H2-Ab1	IDA		Mouse	PMID:14643301
Cellular Component	GO:0009897	external side of plasma membrane	H2-Ab1	IDA		Mouse	PMID:11148202
Cellular Component	GO:0009897	external side of plasma membrane	H2-Ab1	IDA		Mouse	PMID:12801066
Cellular Component	GO:0005794	Golgi apparatus	H2-Ab1	IDA		Mouse	PMID:7679955
Cellular Component	GO:0005622	intracellular anatomical structure	H2-Ab1	IDA		Mouse	PMID:8890155
Cellular Component	GO:0016020	membrane	HLA-DQB1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	H2-Ab1	IDA		Mouse	PMID:7584146
Cellular Component	GO:0042613	MHC class II protein complex	H2-Ab1	IDA		Mouse	PMID:9432982
Cellular Component	GO:0042613	MHC class II protein complex	H2-Ab1	IDA		Mouse	PMID:8638109
Cellular Component	GO:0042613	MHC class II protein complex	H2-Ab1	IDA		Mouse	PMID:8598040
Cellular Component	GO:0042613	MHC class II protein complex	H2-Ab1	IDA		Mouse	PMID:9492004
Cellular Component	GO:0042613	MHC class II protein complex	H2-Ab1	IDA		Mouse	PMID:11148202
Cellular Component	GO:0042613	MHC class II protein complex	H2-Ab1	IDA		Mouse	PMID:8598041
Cellular Component	GO:0042613	MHC class II protein complex	H2-Ab1	IDA		Mouse	PMID:7679955
Cellular Component	GO:0042613	MHC class II protein complex	H2-Ab1	IDA		Mouse	PMID:7985028
Cellular Component	GO:0005771	multivesicular body	H2-Ab1	IDA		Mouse	PMID:11854359
Cellular Component	GO:0005886	plasma membrane	H2-Ab1	IDA		Mouse	PMID:7679955
Cellular Component	GO:0005886	plasma membrane	H2-Ab1	IDA		Mouse	PMID:8890155
Cellular Component	GO:0005886	plasma membrane	H2-Ab1	IDA		Mouse	PMID:8638109
Cellular Component	GO:0005886	plasma membrane	H2-Ab1	IDA		Mouse	PMID:11854359
Cellular Component	GO:0005886	plasma membrane	H2-Ab1	IDA		Mouse	PMID:7985028
Biological Process	GO:0019882	antigen processing and presentation	H2-Ab1	IDA		Mouse	PMID:9432982
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	HLA-DQB1	IDA		Human	PMID:32341563
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Ab1	IDA		Mouse	PMID:9432982
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Ab1	IDA		Mouse	PMID:11714799
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Ab1	IDA		Mouse	PMID:8598040
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Ab1	IDA		Mouse	PMID:11069069
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Ab1	IDA		Mouse	PMID:7679955
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Ab1	IDA		Mouse	PMID:11027433
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Ab1	IDA		Mouse	PMID:8598041
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Ab1	IDA		Mouse	PMID:9492004
Biological Process	GO:0048002	antigen processing and presentation of peptide antigen	H2-Ab1	IDA		Mouse	PMID:11069069
Biological Process	GO:0002344	B cell affinity maturation	H2-Ab1	IDA		Mouse	MGI:MGI:4943414|PMID:1378867
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	RT1-Bb	IEP		Rat	PMID:20377877|RGD:4144112
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	RT1-Bb	IEP		Rat	PMID:12034349|RGD:5147665
Biological Process	GO:0071315	cellular response to morphine	RT1-Bb	IEP		Rat	PMID:14742686|RGD:7488923
Biological Process	GO:0071346	cellular response to type II interferon	H2-Ab1	IDA		Mouse	MGI:MGI:4942269|PMID:9244347
Biological Process	GO:0071346	cellular response to type II interferon	H2-Ab1	IDA		Mouse	MGI:MGI:4942276|PMID:2502420
Biological Process	GO:0071346	cellular response to type II interferon	H2-Ab1	IDA		Mouse	MGI:MGI:4942277|PMID:2493384
Biological Process	GO:0071346	cellular response to type II interferon	H2-Ab1	IDA		Mouse	MGI:MGI:4943415|PMID:1845803
Biological Process	GO:0071346	cellular response to type II interferon	H2-Ab1	IDA		Mouse	MGI:MGI:4942274|PMID:7691725
Biological Process	GO:0050832	defense response to fungus	RT1-Bb	IEP		Rat	PMID:20377877|RGD:4144112
Biological Process	GO:0006959	humoral immune response	HLA-DQB1	IMP		Human	PMID:17050030
Biological Process	GO:0006955	immune response	H2-Ab1	IMP	MGI:MGI:1927483	Mouse	PMID:1909605
Biological Process	GO:0042130	negative regulation of T cell proliferation	RT1-Bb	IDA		Rat	PMID:9834080|RGD:5147666
Biological Process	GO:0046635	positive regulation of alpha-beta T cell activation	H2-Ab1	IMP		Mouse	MGI:MGI:4943670|PMID:9610637
Biological Process	GO:0046635	positive regulation of alpha-beta T cell activation	H2-Ab1	IDA		Mouse	MGI:MGI:4942246|PMID:14607905
Biological Process	GO:0002579	positive regulation of antigen processing and presentation	H2-Ab1	IDA		Mouse	MGI:MGI:4942246|PMID:14607905
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	H2-Ab1	IDA		Mouse	MGI:MGI:4942246|PMID:14607905
Biological Process	GO:0050852	T cell receptor signaling pathway	HLA-DQB1	IDA		Human	PMID:32341563

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern