Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GZMA
  • Mouse genes Gzma
  • Rat genes Gzma
  • Zfish genes gzma,si:dkey-21e2.10,si:dkey-21e2.11,si:dkey-21e2.12,si:dkey-21e2.14,si:dkey-21e2.15,si:dkey-21e2.16,si:dkey-21e2.3,si:dkey-21e2.8,si:dkey-78l4.10,si:dkey-78l4.13,si:dkey-78l4.2,si:dkey-78l4.4,si:dkey-78l4.6,si:dkey-78l4.7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gzma

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	GZMA	IPI	UniProtKB:P27695	Human	PMID:12524539
Molecular Function	GO:0042803	protein homodimerization activity	GZMA	IDA		Human	PMID:12819770
Molecular Function	GO:0004252	serine-type endopeptidase activity	GZMA	IDA		Human	PMID:11331782
Molecular Function	GO:0004252	serine-type endopeptidase activity	GZMA	IDA		Human	PMID:12819770
Molecular Function	GO:0004252	serine-type endopeptidase activity	GZMA	IDA		Human	PMID:32299851
Molecular Function	GO:0004252	serine-type endopeptidase activity	GZMA	IDA		Human	PMID:34022140
Molecular Function	GO:0008236	serine-type peptidase activity	Gzma	IDA		Mouse	PMID:16618603
Molecular Function	GO:0008236	serine-type peptidase activity	Gzma	IDA		Mouse	PMID:35482418
Cellular Component	GO:0005737	cytoplasm	GZMA	IDA		Human	PMID:20038786
Cellular Component	GO:0005737	cytoplasm	GZMA	IDA		Human	PMID:34022140
Cellular Component	GO:0005615	extracellular space	Gzma	IDA		Mouse	PMID:35482418
Cellular Component	GO:0005634	nucleus	Gzma	IDA		Mouse	MGI:MGI:5546004|PMID:1860869
Biological Process	GO:1902483	cytotoxic T cell pyroptotic process	GZMA	IDA		Human	PMID:32299851
Biological Process	GO:0140507	granzyme-mediated programmed cell death signaling pathway	GZMA	IDA		Human	PMID:32299851
Biological Process	GO:0140507	granzyme-mediated programmed cell death signaling pathway	GZMA	IDA		Human	PMID:34022140
Biological Process	GO:0043392	negative regulation of DNA binding	GZMA	IDA		Human	PMID:12524539
Biological Process	GO:0032078	negative regulation of endodeoxyribonuclease activity	GZMA	IDA		Human	PMID:12524539
Biological Process	GO:0051354	negative regulation of oxidoreductase activity	GZMA	IDA		Human	PMID:12524539
Biological Process	GO:0043065	positive regulation of apoptotic process	GZMA	IDA		Human	PMID:12524539
Biological Process	GO:0051604	protein maturation	GZMA	IDA		Human	PMID:32299851
Biological Process	GO:0051604	protein maturation	GZMA	IDA		Human	PMID:34022140
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	GZMA	IDA		Human	PMID:12524539
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	GZMA	IDA		Human	PMID:32299851
Biological Process	GO:0070269	pyroptosis	GZMA	IDA		Human	PMID:32299851
Biological Process	GO:0009617	response to bacterium	Gzma	IEP		Mouse	PMID:23012479

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern