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Gzma
Gene Detail
 Symbol
Name
ID
Gzma
granzyme A
MGI:109266
Synonyms BLT esterase, Ctla3, Ctla-3, Hanukah factor, Hf, H factor, SE1, serine esterase 1, TSP1, TSP-1
Feature Type protein coding gene
Genetic Map
Chromosome 13
63.93 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr13:113093827-113100981 bp, - strand
From NCBI annotation of GRCm38

  7155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: trypsin
Gene Tree: Gzma

Human
homologs
Human Homolog GZMA, granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
NCBI Gene ID 3001
neXtProt AC  NX_P12544
Human Synonyms  CTLA3, HFSP
Human Chr (Location)  5q11-q12; chr5:55102646-55110252 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Gene trapped(1)
 
Homozygotes for a null allele show normal T/NK cell-mediated cytotoxicity, recovery from LCM virus or L. monocytogenes infection, and control of syngeneic tumor growth. Homozygotes for a different null allele show defective CTL cytolysis and increased tumor burden upon challenge with RMAS cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, cytolysis, ...
Component extracellular region, nucleus
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (3)    Images (4)
Theiler Stages: 20, 23
Assay TypeResults
RNA in situ 7
RT-PCR 2
cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(42) Genomic(8) cDNA(32) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000023132 (Evidence)
Entrez Gene14938 (Evidence)
UniGene15510
DFCITC1576902
DoTSDT.91480622, DT.99857470
EC3.4.21.78
Consensus CDS ProjectCCDS26782.1
International Mouse Knockout Project StatusGzma
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14938 NCBI Gene Model | MGI Sequence Detail 7155 C57BL/6J ±  kb
transcript NM_010370 RefSeq | MGI Sequence Detail 878 Not Specified 
polypeptide P11032 UniProt | EBI | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms RFLP(8) : SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000003502 granzyme A
Graphical View of Protein Domain Structure
References (Earliest) J:83 Bunker LE Jr, Hepatic fusion, a new gene in linkage group I of the mouse. J Hered. 1959;50:40-44
(Latest) J:201027 Larena M, et al., Cytolytic effector pathways and IFN-gamma help protect against Japanese encephalitis. Eur J Immunol. 2013 Jul;43(7):1789-98
All references(116)
Other
accession IDs
MGD-MRK-10699, MGD-MRK-2223, MGD-MRK-2233, MGD-MRK-38311, MGI:2145434

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory