Gzma
Gene Detail

Symbol Name ID

Gzma granzyme A MGI:109266

Synonyms

BLT esterase, Ctla3, Ctla-3, Hanukah factor, Hf, H factor, SE1, serine esterase 1, TSP1, TSP-1

Feature Type

protein coding gene

Genetic Map

Chromosome 13

63.93 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(25)

Sequence Map

Chr13:113093827-113100981 bp, - strand From NCBI annotation of GRCm38   7155 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: trypsin
Gene Tree: Gzma

Human homologs

Human Homolog		GZMA, granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
NCBI Gene ID		3001
neXtProt AC		NX_P12544
Human Synonyms		CTLA3, HFSP
Human Chr (Location)		5q11-q12; chr5:54398474-54406080 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygotes for a null allele show normal T/NK cell-mediated cytotoxicity, recovery from LCM virus or L. monocytogenes infection, and control of syngeneic tumor growth. Homozygotes for a different null allele show defective CTL cytolysis and increased tumor burden upon challenge with RMAS cells.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	apoptotic process, cleavage of lamin involved in execution phase of apoptosis, ...
Component	extracellular region
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (3)    Images (4)
Theiler Stages: 20, 23

Assay Type	Results
RNA in situ	7
RT-PCR	2

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(8) cDNA(32) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000023132 (Evidence)
Entrez Gene	14938 (Evidence)
UniGene	15510
DFCI	TC1576902
DoTS	DT.91480622, DT.99857470
EC	3.4.21.78
Consensus CDS Project	CCDS26782.1
International Mouse Knockout Project Status	Gzma

Sequences

Length	Strain/Species
genomic	14938	NCBI Gene Model | MGI Sequence Detail	7155	C57BL/6J
transcript	NM_010370	RefSeq | MGI Sequence Detail	878	Not Specified
polypeptide	P11032	UniProt | EBI | MGI Sequence Detail	260	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(8) : SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000003502	granzyme A

Graphical View of Protein Domain Structure

References

(Earliest) J:83 Bunker LE Jr, Hepatic fusion, a new gene in linkage group I of the mouse. J Hered. 1959;50:40-44
(Latest) J:192609 Bian G, et al., Granzyme B-Mediated Damage of CD8+ T Cells Impairs Graft-versus-Tumor Effect. J Immunol. 2013 Feb 1;190(3):1341-50
All references(113)

Other accession IDs

MGD-MRK-10699, MGD-MRK-2223, MGD-MRK-2233, MGD-MRK-38311, MGI:2145434