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Gzma
Gene Detail
Symbol

Name
ID
Gzma
granzyme A
MGI:109266
Synonyms
BLT esterase, Ctla3, Ctla-3, Hanukah factor, Hf, H factor, SE1, serine esterase 1, TSP1, TSP-1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
63.93 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr13:113093827-113100981 bp, - strand
From NCBI annotation of GRCm38

  7155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: GZMA
Protein SuperFamily: trypsin
Gene Tree: Gzma

Human
homologs
GZMA, granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3001
neXtProt AC: NX_P12544

Human Synonyms: CTLA3, HFSP

Human Chr (Location): 5q11-q12; chr5:55102646-55110252 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show normal T/NK cell-mediated cytotoxicity, recovery from LCM virus or L. monocytogenes infection, and control of syngeneic tumor growth. Homozygotes for a different null allele show defective CTL cytolysis and increased tumor burden upon challenge with RMAS cells.
 
Interactions
Gzma interacts with 21 markers (Mir26a-1, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process apoptotic process, cytolysis, ...
Component extracellular region, nucleus
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (3)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
RT-PCR 2
cDNA source data(29)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gzma    NEW 
Molecular
reagents
All nucleic(42) Genomic(8) cDNA(32) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000023132 (Evidence)
Entrez Gene 14938 (Evidence)
UniGene 15510
DFCI TC1576902
DoTS DT.91480622, DT.99857470
EC 3.4.21.78
Consensus CDS Project CCDS26782.1
International Mouse Phenotyping Consortium Status Gzma
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14938 NCBI Gene Model | MGI Sequence Detail 7155 C57BL/6J ±  kb
transcript NM_010370 RefSeq | MGI Sequence Detail 878 Not Specified 
polypeptide P11032 UniProt | EBI | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(8) : SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
Protein Ontology PR:000003502 granzyme A
Graphical View of Protein Domain Structure
References
(Earliest) J:83 Bunker LE Jr, Hepatic fusion, a new gene in linkage group I of the mouse. J Hered. 1959;50:40-44
(Latest) J:222475 Chaudhri G, et al., Vaccine-induced protection against orthopoxvirus infection is mediated through the combined functions of CD4 T cell-dependent antibody and CD8 T cell responses. J Virol. 2015 Feb;89(3):1889-99
All references(117)
Other
accession IDs
MGD-MRK-10699, MGD-MRK-2223, MGD-MRK-2233, MGD-MRK-38311, MGI:2145434

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory