Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GSR
  • Mouse genes Gsr
  • Rat genes Gsr
  • Zfish genes gsr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gsr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	Gsr	IDA		Rat	PMID:237922|RGD:1625133
Molecular Function	GO:0043295	glutathione binding	Gsr	IDA		Rat	PMID:237922|RGD:1625133
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	Gsr	IDA		Mouse	PMID:1235912
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	Gsr	IDA		Mouse	PMID:7323947
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	Gsr	IDA		Mouse	PMID:8417789
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	Gsr	IDA		Mouse	PMID:2139228
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	Gsr	IDA		Mouse	PMID:204065
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	Gsr	IDA		Rat	PMID:21930213|RGD:10047267
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	Gsr	IDA		Rat	PMID:237922|RGD:1625133
Molecular Function	GO:0042802	identical protein binding	Gsr	IPI	RGD:621747	Rat	PMID:237922|RGD:1625133
Molecular Function	GO:0050661	NADP binding	Gsr	IDA		Rat	PMID:237922|RGD:1625133
Cellular Component	GO:0005829	cytosol	GSR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Gsr	IDA		Rat	PMID:3790139|RGD:1625136
Cellular Component	GO:0009897	external side of plasma membrane	Gsr	IDA		Mouse	PMID:24029230
Cellular Component	GO:0070062	extracellular exosome	GSR	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	GSR	HDA		Human	PMID:23533145
Cellular Component	GO:0005739	mitochondrion	Gsr	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Gsr	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Gsr	IDA		Rat	PMID:6659071|RGD:1625135
Biological Process	GO:0007568	aging	Gsr	IEP		Rat	PMID:3106727|RGD:11059512
Biological Process	GO:0098869	cellular oxidant detoxification	Gsr	IDA		Mouse	MGI:MGI:54294|PMID:1235912
Biological Process	GO:0006749	glutathione metabolic process	Gsr	IDA		Rat	PMID:237922|RGD:1625133
Biological Process	GO:0014823	response to activity	Gsr	IEP		Rat	PMID:21621560|RGD:11059509
Biological Process	GO:0046686	response to cadmium ion	Gsr	IEP		Rat	PMID:24758558|RGD:11059510
Biological Process	GO:0045471	response to ethanol	Gsr	IEP		Rat	PMID:23905773|RGD:7257531
Biological Process	GO:0010041	response to iron(III) ion	Gsr	IEP		Rat	PMID:24388910|RGD:11059508
Biological Process	GO:0002931	response to ischemia	Gsr	IEP		Rat	PMID:9434704|RGD:11059511
Biological Process	GO:0035094	response to nicotine	Gsr	IEP		Rat	PMID:22894698|RGD:7257535
Biological Process	GO:0006979	response to oxidative stress	Gsr	IEP		Rat	PMID:21704983|RGD:11059507
Biological Process	GO:0033189	response to vitamin A	Gsr	IEP		Rat	PMID:22984325|RGD:7257533
Biological Process	GO:0007283	spermatogenesis	Gsr	IMP		Rat	PMID:11874473|RGD:632952

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern