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Gsr Gene Detail
Summary
  • Symbol
    Gsr
  • Name
    glutathione reductase
  • Synonyms
    D8Ertd238e, Gr1, Gr-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95804
    NCBI Gene: 14782
  • Gene Overview
    MyGene.info: GSR
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:33653238-33698162 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 20.69 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    619 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95804
protein coding gene Chr8:33652523-33698163 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033526
protein coding gene Chr8:32112708-32160692 (+)
A/J MGP_AJ_G0033506
protein coding gene Chr8:30886719-30932737 (+)
AKR/J MGP_AKRJ_G0033430
protein coding gene Chr8:31854063-31899556 (+)
BALB/cJ MGP_BALBcJ_G0033502
protein coding gene Chr8:31003741-31052945 (+)
C3H/HeJ MGP_C3HHeJ_G0033214
protein coding gene Chr8:32175340-32222282 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034018
protein coding gene Chr8:33346326-33395621 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030967
protein coding gene Chr8:27688542-27733395 (+)
CAST/EiJ MGP_CASTEiJ_G0032541
protein coding gene Chr8:31602744-31661437 (+)
CBA/J MGP_CBAJ_G0033192
protein coding gene Chr8:34657392-34705082 (+)
DBA/2J MGP_DBA2J_G0033345
protein coding gene Chr8:30865135-30912437 (+)
FVB/NJ MGP_FVBNJ_G0033290
protein coding gene Chr8:30527056-30572971 (+)
LP/J MGP_LPJ_G0033435
protein coding gene Chr8:32066239-32119587 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033332
protein coding gene Chr8:34187774-34238376 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034037
protein coding gene Chr8:31927820-31975713 (+)
PWK/PhJ MGP_PWKPhJ_G0032253
protein coding gene Chr8:30379456-30425113 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032084
protein coding gene Chr8:31211622-31256173 (+)
WSB/EiJ MGP_WSBEiJ_G0032657
protein coding gene Chr8:32072689-32117943 (+)



Homology
more
  • Human Ortholog
    GSR, glutathione-disulfide reductase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GSR, glutathione-disulfide reductase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GR, HEL-75, HEL-S-122m
  • Links
    NCBI Gene ID: 2936
    neXtProt AC: NX_P00390
    UniProt: P00390

  • Chr Location
    8p12; chr8:30678061-30727969 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
A homozygous mutation disrupting this gene between exon 1-2 results in a decreased retinal artery-to-vein ratio. Another small deletion of exons 2-5 has no phenotypic effect. Electrophoretic alleles designated a (C57BL/6, CE) vs. allele b (SJL, SWR) are known.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14782 NCBI Gene Model | MGI Sequence Detail 44925 C57BL/6J ±  kb
    transcript NM_010344 RefSeq | MGI Sequence Detail 2692 C57BL/6  
    polypeptide P47791 UniProt | EBI | MGI Sequence Detail 500 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000008292 glutathione reductase, mitochondrial
    • EC
    • InterPro Domains
      IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamily
      IPR023753 FAD/NAD(P)-binding domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR006322 Glutathione reductase, eukaryote/bacterial
      IPR001100 Pyridine nucleotide-disulphide oxidoreductase, class I
      IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
      IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 4
      cDNA 23
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10240, MGD-MRK-10241, MGI:1098700, MGI:1196262, MGI:2142510, MGI:2175898
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 6
      Gene Ontology 13
      Phenotypes 14
    • Earliest
      J:5572 Nichols EA, et al., Polymorphism and linkage of glutathione reductase in Mus musculus. Biochem Genet. 1975 Jun;13(5-6):323-9
    • Latest
      J:254576 Prigge JR, et al., Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase. Cell Rep. 2017 Jun 27;19(13):2771-2781

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory