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Gsr Gene Detail
Summary
  • Symbol
    Gsr
  • Name
    glutathione reductase
  • Synonyms
    D8Ertd238e, Gr1, Gr-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95804
    NCBI Gene: 14782
  • Gene Overview
    MyGene.info: GSR
Location & Maps
more
  • Sequence Map
    Chr8:33652523-33698163 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45641 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 20.69 cM
  • Mapping Data
    31 experiments
Homology
more
  • Human Ortholog
    GSR, glutathione reductase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GSR, glutathione reductase
    Orthology source: HomoloGene
  • Synonyms
    HEL-75, HEL-S-122m
  • Links
    NCBI Gene ID: 2936
    neXtProt AC: NX_P00390

  • Chr Location
    8p21.1; chr8:30678061-30727969 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GSR associations

Human Disease Mouse Models
       Glutathione Reductase; GSR   OMIM: 138300
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    38
  • Chemically induced (other)
    1
  • Gene trapped
    33
  • Targeted
    4
  • Incidental Mutations
A homozygous mutation disrupting this gene between exon 1-2 results in a decreased retinal artery-to-vein ratio. Another small deletion of exons 2-5 has no phenotypic effect. Electrophoretic alleles designated a (C57BL/6, CE) vs. allele b (SJL, SWR) are known.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016634 VEGA Gene Model | MGI Sequence Detail 45641 C57BL/6J ±  kb
transcript OTTMUST00000040242 VEGA | MGI Sequence Detail 2673 Not Applicable  
polypeptide OTTMUSP00000017970 VEGA | MGI Sequence Detail 500 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    623 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000008292 glutathione reductase, mitochondrial
  • EC
  • InterPro Domains
    IPR016156 FAD/NAD-linked reductase, dimerisation domain
    IPR023753 FAD/NAD(P)-binding domain
    IPR006322 Glutathione reductase, eukaryote/bacterial
    IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
    IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
Molecular
Reagents
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  • All nucleic 28
    Genomic 4
    cDNA 22
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10240, MGD-MRK-10241, MGI:1098700, MGI:1196262, MGI:2142510, MGI:2175898
References
more
  • Summaries
    All 76
    Developmental Gene Expression 5
    Gene Ontology 12
    Phenotypes 12
  • Earliest
    J:5572 Nichols EA, et al., Polymorphism and linkage of glutathione reductase in Mus musculus. Biochem Genet. 1975 Jun;13(5-6):323-9
  • Latest
    J:221873 Eriksson S, et al., Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver. Nat Commun. 2015;6:6479

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory