Gsr
Gene Detail

Symbol Name ID

Gsr glutathione reductase MGI:95804

Synonyms

D8Ertd238e, Gr1, Gr-1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

20.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)

Sequence Map

Chr8:33652523-33698163 bp, + strand From VEGA annotation of GRCm38   45641 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cat, domestic; cattle; chimpanzee; dog, domestic; rabbit, European    (Mammalian Orthology)
Comparative Map (Mouse/Human Gsr ± 2 cM)

Protein SuperFamily: dihydrolipoamide dehydrogenase
Gene Tree: Gsr

Human ortholog

GSR glutathione reductase NCBI Gene ID 2936
Human Chr8:30536435-30585443 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human GSR (1)

Alleles and phenotypes

All alleles(40) : Targeted(2) Gene trapped(37) Chemically induced(1)
 

A homozygous mutation disrupting this gene between exon 1-2 results in a decreased retinal artery-to-vein ratio. Another small deletion of exons 2-5 has no phenotypic effect. Electrophoretic alleles designated a (C57BL/6, CE) vs. allele b (SJL, SWR) are known.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell redox homeostasis, glutathione metabolic process, ...
Component	cytoplasm, cytosol, ...
Function	flavin adenine dinucleotide binding, glutathione binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (37)    Tissues (12)    Images (26)
Theiler Stages: 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	37

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(4) cDNA(22) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016634 (Evidence)
Ensembl Gene Model	ENSMUSG00000031584 (Evidence)
Entrez Gene	14782 (Evidence)
DFCI	TC1574535, TC1753989
DoTS	DT.535094
NIA Mouse Gene Index	U009245
EC	1.8.1.7
Consensus CDS Project	CCDS22235.1
International Mouse Knockout Project Status	Gsr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016634	VEGA Gene Model | MGI Sequence Detail	45641	C57BL/6J
transcript	OTTMUST00000040242	VEGA | MGI Sequence Detail	2673	Not Applicable
polypeptide	OTTMUSP00000017970	VEGA | MGI Sequence Detail	500	Not Applicable

All sequences(45) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(328 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013027	FAD-dependent pyridine nucleotide-disulphide oxidoreductase
InterPro	IPR016156	FAD/NAD-linked reductase, dimerisation
InterPro	IPR006322	Glutathione reductase, eukaryote/bacterial
InterPro	IPR012999	Pyridine nucleotide-disulphide oxidoreductase, class I, active site
InterPro	IPR004099	Pyridine nucleotide-disulphide oxidoreductase, dimerisation
InterPro	IPR023753	Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
InterPro	IPR001327	Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
Protein Ontology	PR:000008292	glutathione reductase, mitochondrial

References

(Earliest) J:5572 Nichols EA, et al., Polymorphism and linkage of glutathione reductase in Mus musculus. Biochem Genet. 1975 Jun;13(5-6):323-9
(Latest) J:181267 Yan J, et al., Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps. J Immunol. 2012 Mar 1;188(5):2316-27
All references(75)

Other accession IDs

MGD-MRK-10240, MGD-MRK-10241, MGI:1098700, MGI:1196262, MGI:2142510, MGI:2175898