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Gsr
Gene Detail
 Symbol
Name
ID
Gsr
glutathione reductase
MGI:95804
Synonyms D8Ertd238e, Gr1, Gr-1
Feature Type protein coding gene
Genetic Map
Chromosome 8
20.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr8:33652523-33698163 bp, + strand
From VEGA annotation of GRCm38

  45641 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:531  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dihydrolipoamide dehydrogenase
Gene Tree: Gsr

Human
homologs
Human Homolog GSR, glutathione reductase
NCBI Gene ID 2936
neXtProt AC  NX_P00390
Human Synonyms  HEL-75
Human Chr (Location)  8p21.1; chr8:30678061-30727969 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GSR
Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Chemically induced (other)(1) Gene trapped(37) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
A homozygous mutation disrupting this gene between exon 1-2 results in a decreased retinal artery-to-vein ratio. Another small deletion of exons 2-5 has no phenotypic effect. Electrophoretic alleles designated a (C57BL/6, CE) vs. allele b (SJL, SWR) are known.
 
Interactions
Gsr interacts with 114 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell redox homeostasis, glutathione metabolic process, ...
Component cytoplasm, cytosol, ...
Function flavin adenine dinucleotide binding, glutathione binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (60)    Tissues (36)    Images (27)
Theiler Stages: 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 60
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(4) cDNA(22) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016634 (Evidence)
Ensembl Gene ModelENSMUSG00000031584 (Evidence)
Entrez Gene14782 (Evidence)
DFCITC1574535, TC1753989
DoTSDT.535094
NIA Mouse Gene IndexU009245
EC1.8.1.7
Consensus CDS ProjectCCDS22235.1
International Mouse Knockout Project StatusGsr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016634 VEGA Gene Model | MGI Sequence Detail 45641 C57BL/6J ±  kb
transcript OTTMUST00000040242 VEGA | MGI Sequence Detail 2673 Not Applicable 
polypeptide OTTMUSP00000017970 VEGA | MGI Sequence Detail 500 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(8)
Polymorphisms SNPs within 2kb(635 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
InterPro IPR016156 FAD/NAD-linked reductase, dimerisation
InterPro IPR006322 Glutathione reductase, eukaryote/bacterial
InterPro IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
InterPro IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation
InterPro IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
InterPro IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
Protein Ontology PR:000008292 glutathione reductase, mitochondrial
References (Earliest) J:5572 Nichols EA, et al., Polymorphism and linkage of glutathione reductase in Mus musculus. Biochem Genet. 1975 Jun;13(5-6):323-9
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(79)
Other
accession IDs
MGD-MRK-10240, MGD-MRK-10241, MGI:1098700, MGI:1196262, MGI:2142510, MGI:2175898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory