Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRB14
  • Mouse genes Grb14
  • Rat genes Grb14
  • Zfish genes grb14
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grb14

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0060090	molecular adaptor activity	GRB14	EXP		Human	PMID:14623073
Molecular Function	GO:0140678	molecular function inhibitor activity	Grb14	EXP		Rat	PMID:14623073|RGD:12793049
Molecular Function	GO:0140678	molecular function inhibitor activity	Grb14	EXP		Rat	PMID:15465854|RGD:152995576
Molecular Function	GO:0051219	phosphoprotein binding	Grb14	IPI	RGD:2917	Rat	PMID:9748281|RGD:61620
Molecular Function	GO:0005515	protein binding	GRB14	IPI	UniProtKB:P14373	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRB14	IPI	UniProtKB:Q08379	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Grb14	IPI	UniProtKB:P29973	Mouse	MGI:MGI:4887285|PMID:20890309
Molecular Function	GO:0005515	protein binding	Grb14	IPI	UniProtKB:P11362	Rat	PMID:20932831|RGD:8554162
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Grb14	IDA		Mouse	PMID:10713090
Molecular Function	GO:0030971	receptor tyrosine kinase binding	GRB14	IPI	UniProtKB:P06213	Human	PMID:16246733
Cellular Component	GO:0005737	cytoplasm	GRB14	IDA		Human	PMID:11278563
Cellular Component	GO:0005737	cytoplasm	Grb14	IDA		Rat	PMID:18657188|RGD:2307023
Cellular Component	GO:0005768	endosome	Grb14	IDA		Rat	PMID:18657188|RGD:2307023
Cellular Component	GO:0005768	endosome	Grb14	IDA		Rat	PMID:19834685|RGD:2325191
Cellular Component	GO:0005794	Golgi apparatus	Grb14	IDA		Rat	PMID:18657188|RGD:2307023
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	GRB14	IDA		Human	PMID:11278563
Cellular Component	GO:0005886	plasma membrane	GRB14	IDA		Human	PMID:11278563
Cellular Component	GO:0005886	plasma membrane	Grb14	IDA		Rat	PMID:18657188|RGD:2307023
Biological Process	GO:0032869	cellular response to insulin stimulus	Grb14	IMP		Rat	PMID:14623073|RGD:12793049
Biological Process	GO:0031101	fin regeneration	grb14	IMP	ZFIN:ZDB-GENO-190104-2	Zfish	PMID:28871129
Biological Process	GO:0008286	insulin receptor signaling pathway	Grb14	IDA		Rat	PMID:9748281|RGD:61620
Biological Process	GO:0035556	intracellular signal transduction	Grb14	IEP		Rat	PMID:9748281|RGD:61620
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	GRB14	IMP		Human	PMID:16246733
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Grb14	IMP		Rat	PMID:18657188|RGD:2307023
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Grb14	IDA		Rat	PMID:9748281|RGD:61620
Biological Process	GO:1904145	negative regulation of meiotic cell cycle process involved in oocyte maturation	Grb14	IMP		Rat	PMID:14623073|RGD:12793049

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern