Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GPX4
  • Mouse genes Gpx4
  • Rat genes Gpx4
  • Zfish genes gpx4a,gpx4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gpx4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004602	glutathione peroxidase activity	GPX4	IMP		Human	PMID:17630701
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx4	IDA		Mouse	PMID:19890015
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx4	IDA		Mouse	PMID:11344099
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx4	IDA		Rat	PMID:16140890|RGD:1624364
Molecular Function	GO:0042802	identical protein binding	GPX4	IMP		Human	PMID:17630701
Molecular Function	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	GPX4	IDA		Human	PMID:11115402
Molecular Function	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	Gpx4	IDA		Mouse	MGI:MGI:5615528|PMID:25402683
Molecular Function	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	Gpx4	IDA		Mouse	MGI:MGI:6114953|PMID:29290465
Molecular Function	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	Gpx4	IDA		Rat	PMID:8749327|RGD:68791
Molecular Function	GO:0005515	protein binding	GPX4	IPI	UniProtKB:P21754	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	GPX4	IPI	UniProtKB:Q05996	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	GPX4	IPI	UniProtKB:Q12836	Human	PMID:23355646
Molecular Function	GO:0008430	selenium binding	Gpx4	IDA		Rat	PMID:8749327|RGD:68791
Cellular Component	GO:0005829	cytosol	GPX4	IDA		Human	PMID:11115402
Cellular Component	GO:0005829	cytosol	Gpx4	IDA		Mouse	PMID:19890015
Cellular Component	GO:0005829	cytosol	Gpx4	IDA		Mouse	PMID:12566075
Cellular Component	GO:0070062	extracellular exosome	GPX4	HDA		Human	PMID:19056867
Cellular Component	GO:0005743	mitochondrial inner membrane	Gpx4	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005739	mitochondrion	Gpx4	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Gpx4	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Gpx4	IDA		Mouse	PMID:15888450
Cellular Component	GO:0005739	mitochondrion	Gpx4	IDA		Mouse	PMID:12566075
Cellular Component	GO:0005635	nuclear envelope	Gpx4	IDA		Mouse	PMID:12566075
Cellular Component	GO:0005634	nucleus	GPX4	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	Gpx4	IDA		Mouse	PMID:11344099
Cellular Component	GO:0032991	protein-containing complex	GPX4	IMP		Human	PMID:17630701
Biological Process	GO:0007568	aging	Gpx4	IEP		Rat	PMID:17021340|RGD:2306622
Biological Process	GO:0019369	arachidonic acid metabolic process	GPX4	IDA		Human	PMID:11115402
Biological Process	GO:0006325	chromatin organization	Gpx4	IDA		Mouse	PMID:11344099
Biological Process	GO:0006749	glutathione metabolic process	Gpx4	IDA		Rat	PMID:16140890|RGD:1624364
Biological Process	GO:0019372	lipoxygenase pathway	GPX4	IDA		Human	PMID:11115402
Biological Process	GO:0110076	negative regulation of ferroptosis	Gpx4	IMP		Mouse	MGI:MGI:5615528|PMID:25402683
Biological Process	GO:0110076	negative regulation of ferroptosis	Gpx4	IMP		Mouse	MGI:MGI:6114953|PMID:29290465
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	gpx4b	IMP	ZFIN:ZDB-GENO-171018-1	Zfish	PMID:28302747
Biological Process	GO:0051258	protein polymerization	GPX4	IMP		Human	PMID:17630701
Biological Process	GO:0050727	regulation of inflammatory response	Gpx4	IMP		Rat	PMID:12397078|RGD:728699
Biological Process	GO:0032355	response to estradiol	Gpx4	IEP		Rat	PMID:17211248|RGD:2306621
Biological Process	GO:0006979	response to oxidative stress	Gpx4	IMP		Mouse	MGI:MGI:5615528|PMID:25402683
Biological Process	GO:0006979	response to oxidative stress	Gpx4	IMP		Mouse	MGI:MGI:6114953|PMID:29290465
Biological Process	GO:0007283	spermatogenesis	Gpx4	IMP		Mouse	MGI:MGI:5693989|PMID:25922076
Biological Process	GO:0007283	spermatogenesis	Gpx4	IDA		Mouse	PMID:11344099

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern