Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GPRC5B
  • Mouse genes Gprc5b
  • Rat genes Gprc5b
  • Zfish genes gprc5ba,gprc5bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gprc5b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030295	protein kinase activator activity	GPRC5B	IDA		Human	PMID:23169819
Molecular Function	GO:0019901	protein kinase binding	Gprc5b	IPI	UniProtKB:P39688	Mouse	MGI:MGI:5545939|PMID:23169819
Cellular Component	GO:0009986	cell surface	Gprc5b	IDA		Mouse	MGI:MGI:5543849|PMID:24089469
Cellular Component	GO:0005829	cytosol	GPRC5B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	GPRC5B	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	GPRC5B	IDA		Human	PMID:21557262
Cellular Component	GO:0070062	extracellular exosome	GPRC5B	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	GPRC5B	HDA		Human	PMID:16502470
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	GPRC5B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045121	membrane raft	Gprc5b	IDA		Mouse	PMID:23169819
Cellular Component	GO:0005730	nucleolus	GPRC5B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	GPRC5B	IDA		Human	GO_REF:0000052
Biological Process	GO:0042593	glucose homeostasis	Gprc5b	IMP	MGI:MGI:5293387	Mouse	PMID:23169819
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Gprc5b	IGI	MGI:MGI:95602	Mouse	PMID:23169819
Biological Process	GO:0007626	locomotory behavior	Gprc5b	IMP	MGI:MGI:5293387	Mouse	PMID:21840300
Biological Process	GO:0001945	lymph vessel development	gprc5ba	IMP	ZFIN:ZDB-MRPHLNO-220929-1	Zfish	PMID:35628521
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Gprc5b	IMP		Mouse	MGI:MGI:5543849|PMID:24089469
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Gprc5b	IMP		Mouse	MGI:MGI:5545939|PMID:23169819
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Gprc5b	IGI	MGI:MGI:95602	Mouse	PMID:23169819
Biological Process	GO:0050729	positive regulation of inflammatory response	Gprc5b	IMP		Mouse	MGI:MGI:5545939|PMID:23169819
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Gprc5b	IMP		Mouse	MGI:MGI:5545939|PMID:23169819
Biological Process	GO:0045666	positive regulation of neuron differentiation	Gprc5b	IMP		Mouse	MGI:MGI:5543849|PMID:24089469
Biological Process	GO:0010976	positive regulation of neuron projection development	Gprc5b	IDA		Mouse	PMID:20436672
Biological Process	GO:0045860	positive regulation of protein kinase activity	Gprc5b	IMP	MGI:MGI:5293387	Mouse	PMID:23169819
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Gprc5b	IMP	MGI:MGI:5293387	Mouse	PMID:23169819
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Gprc5b	IMP		Mouse	MGI:MGI:5545939|PMID:23169819
Biological Process	GO:0006468	protein phosphorylation	Gprc5b	IMP	MGI:MGI:5293387	Mouse	PMID:23169819

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern