Gprc5b MGI Mouse Gene Detail - MGI:1927596 - G protein-coupled receptor, family C, group 5, member B

Gprc5b Gene Detail

Symbol

Gprc5b
Name

G protein-coupled receptor, family C, group 5, member B
Synonyms

hypothetical protein, clone 2-63

Feature Type

protein coding gene
IDs

MGI:1927596
NCBI Gene: 64297
Gene Overview

MyGene.info: GPRC5B
Alliance

gene page

Sequence Map

Chr7:118972047-118995211 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

23165 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 63.72 cM, cytoband F3
Mapping Data

3 experiments

Human Ortholog

GPRC5B, G protein-coupled receptor class C group 5 member B

Vertebrate Orthologs

10

Human Ortholog

GPRC5B, G protein-coupled receptor class C group 5 member B
Orthology source: HomoloGene, HGNC
Synonyms

RAIG2, RAIG-2
Links

HGNC:13308

NCBI Gene ID: 51704

neXtProt AC: NX_Q9NZH0

UniProt: Q9NZH0
Chr Location

16p12.3; chr16:19858971-19886045 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9435
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: GPRC5B
Protein SuperFamily

retinoic acid-induced G protein-coupled receptor
Gene Tree

Gprc5b

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Phenotype Summary

7 phenotypes from 3 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter allele exhibit partial neonatal and postnatal lethality, altered spontaneous activity pattern, and decreased response to a new environment.

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All GO Annotations

43
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

60
Tissues

44
cDNA Data

6
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gprc5b

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Gprc5b interacts with 339 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

32
RefSeq

4
UniProt

3
CCDS

CCDS21777.1, CCDS85400.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000059047	VEGA Gene Model \| MGI Sequence Detail	23165	C57BL/6J	± kb
transcript	OTTMUST00000144856	VEGA \| MGI Sequence Detail	1416	Not Applicable
polypeptide	OTTMUSP00000075467	VEGA \| MGI Sequence Detail	411	Not Applicable

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SNPs within 2kb

223 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000008195 G-protein coupled receptor family C group 5 member B

(term hierarchy)
InterPro Domains

IPR017978 GPCR family 3, C-terminal

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All nucleic 8

cDNA 6

Primer pair 1

Other 1

Microarray probesets 6

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MGI:2142210

Summaries

All 46

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 12
Earliest

J:64911 Inoue S, et al., Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Biochem Biophys Res Commun. 2000 Feb 16;268(2):553-61
Latest

J:259479 Sano T, et al., Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning. Neurosci Res. 2018 Feb 23;

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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