Gprc5b
Gene Detail

Symbol

Name
ID

Gprc5b
G protein-coupled receptor, family C, group 5, member B
MGI:1927596

Synonyms

hypothetical protein, clone 2-63

Feature Type

protein coding gene

Genetic Map

Chromosome 7
63.72 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:118972040-118995211 bp, - strand From NCBI annotation of GRCm38   23172 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:9435  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: retinoic acid-induced G protein-coupled receptor
Gene Tree: Gprc5b

Human
homologs

Human Homolog		GPRC5B, G protein-coupled receptor, class C, group 5, member B
NCBI Gene ID		51704
neXtProt AC		NX_Q9NZH0
Human Synonyms		RAIG2, RAIG-2
Human Chr (Location)		16p12; chr16:19858970-19886045 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a reporter allele exhibit partial neonatal and postnatal lethality, altered spontaneous activity pattern, and decreased response to a new environment.

 

Interactions

Gprc5b interacts with 340 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (34 annotations)

Process	glucose homeostasis, G-protein coupled receptor signaling pathway, ...
Component	cell surface, extracellular space, ...
Function	G-protein coupled receptor activity, protein kinase activator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (52)    Tissues (38)    Images (2)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	27
RT-PCR	25

cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(6)

Other database
links

Ensembl Gene Model	ENSMUSG00000008734 (Evidence)
Entrez Gene	64297 (Evidence)
NIA Mouse Gene Index	U029178
Consensus CDS Project	CCDS21777.1
International Mouse Knockout Project Status	Gprc5b

Sequences

Length	Strain/Species
genomic	64297	NCBI Gene Model | MGI Sequence Detail	23172	C57BL/6J
transcript	NM_022420	RefSeq | MGI Sequence Detail	4525	C57BL/6
polypeptide	Q923Z0	UniProt | EBI | MGI Sequence Detail	410	Not Applicable

All sequences(24) RefSeq(4) UniProt(5)

Polymorphisms

SNPs within 2kb(224 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017978	GPCR, family 3, C-terminal
Protein Ontology	PR:000008195	G-protein coupled receptor family C group 5 member B

Graphical View of Protein Domain Structure

References

(Earliest) J:64911 Inoue S, et al., Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Biochem Biophys Res Commun. 2000 Feb 16;268(2):553-61
(Latest) J:204990 Kurabayashi N, et al., The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex. Development. 2013 Nov;140(21):4335-46
All references(39)

Other
accession IDs

MGI:2142210