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Gprc5b Gene Detail
Summary
  • Symbol
    Gprc5b
  • Name
    G protein-coupled receptor, family C, group 5, member B
  • Synonyms
    hypothetical protein, clone 2-63
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927596
    NCBI Gene: 64297
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:118571270-118594434 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 63.72 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    601 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927596
 protein coding gene Chr7:118571263-118594434 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032907
 protein coding gene Chr7:122859662-122882850 (-)
A/J MGP_AJ_G0032890
 protein coding gene Chr7:119718893-119742076 (-)
AKR/J MGP_AKRJ_G0032822
 protein coding gene Chr7:122782233-122805402 (-)
BALB/cJ MGP_BALBcJ_G0032895
 protein coding gene Chr7:119445302-119468531 (-)
C3H/HeJ MGP_C3HHeJ_G0032605
 protein coding gene Chr7:122680891-122704081 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033401
 protein coding gene Chr7:127750576-127773737 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030373
 protein coding gene Chr7:121151515-121174635 (-)
CAST/EiJ MGP_CASTEiJ_G0031933
 protein coding gene Chr7:114445510-114480151 (-)
CBA/J MGP_CBAJ_G0032578
 protein coding gene Chr7:132021068-132044256 (-)
DBA/2J MGP_DBA2J_G0032730
 protein coding gene Chr7:117753771-117776945 (-)
FVB/NJ MGP_FVBNJ_G0032683
 protein coding gene Chr7:117597211-117621259 (-)
LP/J MGP_LPJ_G0032824
 protein coding gene Chr7:124322612-124345790 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032715
 protein coding gene Chr7:133494455-133517609 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033421
 protein coding gene Chr7:121785423-121808602 (-)
PWK/PhJ MGP_PWKPhJ_G0031641
 protein coding gene Chr7:110653040-110686359 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031488
 protein coding gene Chr7:108505099-108533973 (-)
WSB/EiJ MGP_WSBEiJ_G0032046
 protein coding gene Chr7:122668581-122691705 (-)



Homology
more
  • Human Ortholog
    GPRC5B, G protein-coupled receptor class C group 5 member B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPRC5B, G protein-coupled receptor class C group 5 member B
  • Synonyms
    MLC3, RAIG-2, RAIG2
  • Links
    NCBI Gene ID: 51704
    UniProt: Q9NZH0

  • Chr Location
    16p12.3; chr16:19856691-19886167 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GPRC5B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit partial neonatal and postnatal lethality, altered spontaneous activity pattern, and decreased response to a new environment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    834
  • Tissues
    75
  • cDNA Data
    7
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008734 Ensembl Gene Model | MGI Sequence Detail 23165 C57BL/6J ±  kb
    transcript ENSMUST00000208394 Ensembl | MGI Sequence Detail 1416 Not Applicable  
    polypeptide ENSMUSP00000146777 Ensembl | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142210
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 11
      Gene Ontology 12
      Phenotypes 19
    • Earliest
      J:64911 Inoue S, et al., Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Biochem Biophys Res Commun. 2000 Feb 16;268(2):553-61
    • Latest
      J:363500 Kwon J, et al., Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling. Nat Commun. 2025 Feb 7;16(1):1448
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory