Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GNAI2
  • Mouse genes Gnai2
  • Rat genes Gnai2
  • Zfish genes gnai2a,gnai2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gnai2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:Q99750	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:P14598	Human	PMID:16782902
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:P19878	Human	PMID:16782902
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:P42866	Human	PMID:18599439
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:P32302	Human	PMID:23773523
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:P32302	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:O76081-6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:P60410	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:Q15654	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:Q9Y4H4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:P62879	Human	PMID:28219978
Molecular Function	GO:0005515	protein binding	GNAI2	IPI	UniProtKB:Q8IVA1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Gnai2	IPI	PR:P30557	Mouse	PMID:8076637
Molecular Function	GO:0005515	protein binding	Gnai2	IPI	UniProtKB:O08773	Rat	PMID:11387333|RGD:7207387
Molecular Function	GO:0005515	protein binding	Gnai2	IPI	UniProtKB:O08774	Rat	PMID:11387333|RGD:7207387
Molecular Function	GO:0005515	protein binding	Gnai2	IPI	RGD:727957	Rat	PMID:12509430|RGD:633903
Cellular Component	GO:0044297	cell body	Gnai2	IDA		Mouse	PMID:11685543
Cellular Component	GO:0005813	centrosome	GNAI2	IDA		Human	PMID:17635935
Cellular Component	GO:0005737	cytoplasm	GNAI2	IDA		Human	PMID:17635935
Cellular Component	GO:0005829	cytosol	GNAI2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Gnai2	IDA		Rat	PMID:12573529|RGD:1598462
Cellular Component	GO:0030425	dendrite	Gnai2	IDA		Mouse	PMID:11685543
Cellular Component	GO:0070062	extracellular exosome	GNAI2	HDA		Human	PMID:12519789
Cellular Component	GO:0070062	extracellular exosome	GNAI2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	GNAI2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	GNAI2	HDA		Human	PMID:20458337
Cellular Component	GO:1903561	extracellular vesicle	GNAI2	HDA		Human	PMID:24769233
Cellular Component	GO:0016020	membrane	GNAI2	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Gnai2	IDA		Rat	PMID:15961389|RGD:1598749
Cellular Component	GO:0016020	membrane	Gnai2	IDA		Rat	PMID:16741924|RGD:2312769
Cellular Component	GO:0045121	membrane raft	Gnai2	IDA		Rat	PMID:17157995|RGD:1625132
Cellular Component	GO:0030496	midbody	GNAI2	IDA		Human	PMID:17635935
Cellular Component	GO:0098992	neuronal dense core vesicle	Gnai2	IDA		Mouse	PMID:21321602
Cellular Component	GO:0098992	neuronal dense core vesicle	Gnai2	EXP		Mouse	PMID:21321602
Cellular Component	GO:0005654	nucleoplasm	GNAI2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Gnai2	IDA		Rat	PMID:12573529|RGD:1598462
Cellular Component	GO:0005886	plasma membrane	GNAI2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	GNAI2	IDA		Human	PMID:17635935
Cellular Component	GO:0005886	plasma membrane	Gnai2	IDA		Rat	PMID:12573529|RGD:1598462
Cellular Component	GO:0005886	plasma membrane	Gnai2	IDA		Rat	PMID:16870394|RGD:8553973
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnai2	IMP		Rat	PMID:27912212|RGD:13507308
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Gnai2	IMP	MGI:MGI:2152603	Mouse	PMID:8622915
Biological Process	GO:0051301	cell division	GNAI2	IMP		Human	PMID:17635935
Biological Process	GO:0008283	cell population proliferation	Gnai2	IPI	PR:Q99JI6	Mouse	PMID:14712229
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	Gnai2	IMP	MGI:MGI:2152603	Mouse	PMID:11299198
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	Gnai2	IDA		Rat	PMID:11923410|RGD:625670
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Gnai2	IDA		Rat	PMID:11923410|RGD:625670
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	Gnai2	IDA		Rat	PMID:11923410|RGD:625670
Biological Process	GO:0140199	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	Gnai2	IDA		Rat	PMID:12631586|RGD:13508593
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	Gnai2	IMP		Rat	PMID:25633408|RGD:13507311
Biological Process	GO:0045955	negative regulation of calcium ion-dependent exocytosis	Gnai2	IMP		Rat	PMID:11533141|RGD:13508598
Biological Process	GO:1903614	negative regulation of protein tyrosine phosphatase activity	Gnai2	IMP		Rat	PMID:11500506|RGD:13508599
Biological Process	GO:0050805	negative regulation of synaptic transmission	Gnai2	IDA		Rat	PMID:11923410|RGD:625670
Biological Process	GO:0030335	positive regulation of cell migration	Gnai2	IMP		Rat	PMID:22936789|RGD:13507312
Biological Process	GO:0008284	positive regulation of cell population proliferation	GNAI2	IMP		Human	PMID:21079996
Biological Process	GO:0008284	positive regulation of cell population proliferation	Gnai2	IMP		Rat	PMID:12573529|RGD:1598462
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Gnai2	IMP		Rat	PMID:11495629|RGD:728462
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Gnai2	IMP		Rat	PMID:11500506|RGD:13508599
Biological Process	GO:0033864	positive regulation of NAD(P)H oxidase activity	Gnai2	IMP		Rat	PMID:27912212|RGD:13507308
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Gnai2	IMP		Rat	PMID:15272018|RGD:13508591
Biological Process	GO:0035815	positive regulation of renal sodium excretion	Gnai2	IMP		Rat	PMID:22459149|RGD:13507313
Biological Process	GO:0032930	positive regulation of superoxide anion generation	Gnai2	IMP		Rat	PMID:27912212|RGD:13507308
Biological Process	GO:0035810	positive regulation of urine volume	Gnai2	IMP		Rat	PMID:22459149|RGD:13507313
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Gnai2	IMP		Rat	PMID:27912212|RGD:13507308
Biological Process	GO:0051924	regulation of calcium ion transport	Gnai2	IDA		Rat	PMID:10639178|RGD:1598463

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern