Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GLIS1
  • Mouse genes Glis1
  • Rat genes Glis1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Glis1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Glis1	IDA		Mouse	PMID:12385751
Molecular Function	GO:0003677	DNA binding	Glis1	IDA		Mouse	PMID:12042312
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Glis1	IDA		Mouse	MGI:MGI:2385553|PMID:12042312
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Glis1	IDA		Mouse	MGI:MGI:2385553|PMID:12042312
Molecular Function	GO:0005515	protein binding	GLIS1	IPI	UniProtKB:P35321	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS1	IPI	UniProtKB:Q8IYP9	Human	PMID:32296183
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Glis1	IDA		Mouse	MGI:MGI:2385553|PMID:12042312
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	GLIS1	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Glis1	IDA		Mouse	PMID:12042312
Biological Process	GO:0045444	fat cell differentiation	Glis1	IMP		Mouse	MGI:MGI:6294234|PMID:30544251
Biological Process	GO:0010454	negative regulation of cell fate commitment	Glis1	IMP		Mouse	MGI:MGI:6294234|PMID:30544251
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Glis1	IDA		Mouse	PMID:12042312
Biological Process	GO:0001649	osteoblast differentiation	Glis1	IMP		Mouse	MGI:MGI:6294234|PMID:30544251
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Glis1	IDA		Mouse	PMID:12042312
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Glis1	IDA		Mouse	MGI:MGI:2385553|PMID:12042312
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Glis1	IDA		Mouse	PMID:12385751

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern