Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GJA4
  • Mouse genes Gja4
  • Rat genes Gja4
  • Zfish genes gja12.1,gja13.1,gja13.2,gja4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gja4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	GJA4	IPI	UniProtKB:P35372	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	GJA4	IPI	UniProtKB:P35372	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	GJA4	IPI	UniProtKB:P60033	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA4	IPI	UniProtKB:Q5J8X5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA4	IPI	UniProtKB:Q8N661	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA4	IPI	UniProtKB:Q96FB2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	gja4	IPI	ZFIN:ZDB-GENE-031001-2	Zfish	PMID:25915619
Cellular Component	GO:0005922	connexin complex	Gja4	IDA		Rat	PMID:9851942|RGD:1598435
Cellular Component	GO:0005921	gap junction	Gja4	IDA		Rat	PMID:10894813|RGD:1598434
Biological Process	GO:0001568	blood vessel development	Gja4	IMP	MGI:MGI:2181813	Mouse	PMID:12435353
Biological Process	GO:0006816	calcium ion transport	Gja4	IMP		Rat	PMID:15319213|RGD:1598436
Biological Process	GO:0007267	cell-cell signaling	Gja4	IMP		Rat	PMID:15319213|RGD:1598436
Biological Process	GO:0003158	endothelium development	Gja4	IEP		Rat	PMID:10990491|RGD:7207853
Biological Process	GO:0043473	pigmentation	gja4	IMP	ZFIN:ZDB-GENO-160427-7	Zfish	PMID:26598520
Biological Process	GO:0043473	pigmentation	gja4	IMP	ZFIN:ZDB-GENO-150312-21	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja4	IGI	ZFIN:ZDB-GENO-150312-18	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja4	IGI	ZFIN:ZDB-GENO-150312-17	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja4	IMP	ZFIN:ZDB-GENO-160428-1	Zfish	PMID:26598520
Biological Process	GO:0043473	pigmentation	gja4	IMP	ZFIN:ZDB-GENO-150312-19	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja4	IGI	ZFIN:ZDB-GENO-151209-14	Zfish	PMID:25915619
Biological Process	GO:0043473	pigmentation	gja4	IGI	ZFIN:ZDB-GENO-150316-6	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja4	IMP	ZFIN:ZDB-GENO-150316-4	Zfish	PMID:25535837
Biological Process	GO:0048265	response to pain	Gja4	IEP		Rat	PMID:11978404|RGD:728686

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern