About   Help   FAQ
Gja4 Gene Detail
Summary
  • Symbol
    Gja4
  • Name
    gap junction protein, alpha 4
  • Synonyms
    Cnx37, connexin 37, Cx37, Gja-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95715
    NCBI Gene: 14612
  • Gene Overview
    MyGene.info: GJA4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:127311421-127314039 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 61.47 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95715
protein coding gene Chr4:127311420-127314039 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028796
protein coding gene Chr4:129061477-129064095 (-)
A/J MGP_AJ_G0028755
protein coding gene Chr4:123971469-123974087 (-)
AKR/J MGP_AKRJ_G0028708
protein coding gene Chr4:127383791-127386409 (-)
BALB/cJ MGP_BALBcJ_G0028778
protein coding gene Chr4:124536488-124539106 (-)
C3H/HeJ MGP_C3HHeJ_G0028492
protein coding gene Chr4:127447631-127450249 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029220
protein coding gene Chr4:133968206-133970824 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026493
protein coding gene Chr4:117089181-117091784 (-)
CAST/EiJ MGP_CASTEiJ_G0027925
protein coding gene Chr4:125580174-125582796 (-)
CBA/J MGP_CBAJ_G0028458
protein coding gene Chr4:137242095-137244713 (-)
DBA/2J MGP_DBA2J_G0028607
protein coding gene Chr4:124410909-124413527 (-)
FVB/NJ MGP_FVBNJ_G0028574
protein coding gene Chr4:123074143-123076761 (-)
LP/J MGP_LPJ_G0028708
protein coding gene Chr4:129349072-129351690 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028600
protein coding gene Chr4:142217665-142220287 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029258
protein coding gene Chr4:127751720-127754338 (-)
PWK/PhJ MGP_PWKPhJ_G0027646
protein coding gene Chr4:120923872-120926501 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027473
protein coding gene Chr4:123576101-123578721 (-)
WSB/EiJ MGP_WSBEiJ_G0028005
protein coding gene Chr4:127858580-127861198 (-)



Homology
more
  • Human Ortholog
    GJA4, gap junction protein alpha 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GJA4, gap junction protein alpha 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CX37
  • Links
    NCBI Gene ID: 2701
    neXtProt AC: NX_P35212
    UniProt: P35212

  • Chr Location
    1p34.3; chr1:34792958-34795747 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1556
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GJA4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutant females are sterile and oocyte development arrests prior to achieving meiotic competence. There is a lack of mature Graafian follicles, failure to ovulate, and formation of premature corpora lutea.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050234 Ensembl Gene Model | MGI Sequence Detail 2619 C57BL/6J ±  kb
    transcript ENSMUST00000053753 Ensembl | MGI Sequence Detail 1685 Not Applicable  
    polypeptide ENSMUSP00000062320 Ensembl | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 1
      cDNA 35
      Primer pair 8
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10081, MGD-MRK-10087, MGI:2140457, MGI:2140606
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 48
      Gene Ontology 4
      Phenotypes 36
    • Earliest
      J:11073 Willecke K, et al., Six genes of the human connexin gene family coding for gap junctional proteins are assigned to four different human chromosomes. Eur J Cell Biol. 1990 Dec;53(2):275-80
    • Latest
      J:258858 Allagnat F, et al., Connexin37 reduces smooth muscle cell proliferation and intimal hyperplasia in a mouse model of carotid artery ligation. Cardiovasc Res. 2017 Jun 1;113(7):805-816

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory