Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GDF3
  • Mouse genes Gdf3
  • Rat genes Gdf3
  • Zfish genes gdf3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gdf3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Gdf3	IPI	PR:P51865	Mouse	PMID:16368929
Molecular Function	GO:0019901	protein kinase binding	GDF3	IPI	UniProtKB:Q8NER5	Human	PMID:21805089
Cellular Component	GO:0005737	cytoplasm	GDF3	IDA		Human	PMID:21805089
Cellular Component	GO:0032991	protein-containing complex	gdf3	IPI	ZFIN:ZDB-GENE-990415-256	Zfish	PMID:29140251
Cellular Component	GO:0032991	protein-containing complex	gdf3	IPI	ZFIN:ZDB-GENE-990415-181	Zfish	PMID:29140251
Biological Process	GO:0009798	axis specification	gdf3	IMP	ZFIN:ZDB-GENO-181002-8	Zfish	PMID:29140249
Biological Process	GO:0030509	BMP signaling pathway	gdf3	IMP	ZFIN:ZDB-GENO-181002-11	Zfish	PMID:29140250
Biological Process	GO:0060027	convergent extension involved in gastrulation	gdf3	IMP	ZFIN:ZDB-MRPHLNO-171103-2	Zfish	PMID:24892953
Biological Process	GO:0060027	convergent extension involved in gastrulation	gdf3	IGI	ZFIN:ZDB-GENE-030131-7093	Zfish	PMID:24892953
Biological Process	GO:0060027	convergent extension involved in gastrulation	gdf3	IMP	ZFIN:ZDB-MRPHLNO-100312-2	Zfish	PMID:24892953
Biological Process	GO:0007492	endoderm development	Gdf3	IGI	MGI:MGI:95683	Mouse	PMID:17936261
Biological Process	GO:0007492	endoderm development	Gdf3	IMP	MGI:MGI:3612535	Mouse	PMID:16368929
Biological Process	GO:0001654	eye development	GDF3	IMP		Human	PMID:19864492
Biological Process	GO:0048859	formation of anatomical boundary	Gdf3	IMP	MGI:MGI:3612535	Mouse	PMID:16368929
Biological Process	GO:0001947	heart looping	gdf3	IMP	ZFIN:ZDB-MRPHLNO-100312-2	Zfish	PMID:22613031
Biological Process	GO:0001701	in utero embryonic development	Gdf3	IGI	MGI:MGI:95683	Mouse	PMID:17936261
Biological Process	GO:0001701	in utero embryonic development	Gdf3	IMP	MGI:MGI:3764814	Mouse	PMID:17936261
Biological Process	GO:0001701	in utero embryonic development	Gdf3	IMP	MGI:MGI:3612535	Mouse	PMID:16368929
Biological Process	GO:0060972	left/right pattern formation	gdf3	IMP	ZFIN:ZDB-MRPHLNO-100312-2	Zfish	PMID:29140250
Biological Process	GO:0007498	mesoderm development	Gdf3	IGI	MGI:MGI:95683	Mouse	PMID:17936261
Biological Process	GO:0007498	mesoderm development	Gdf3	IMP	MGI:MGI:3612535	Mouse	PMID:16368929
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	GDF3	IDA		Human	PMID:18823971
Biological Process	GO:0045605	negative regulation of epidermal cell differentiation	GDF3	IDA		Human	PMID:18823971
Biological Process	GO:0045662	negative regulation of myoblast differentiation	Gdf3	IMP		Mouse	PMID:23844157
Biological Process	GO:0048666	neuron development	gdf3	IMP	ZFIN:ZDB-MRPHLNO-100312-2	Zfish	PMID:22613031
Biological Process	GO:0038092	nodal signaling pathway	gdf3	IMP	ZFIN:ZDB-GENO-181002-11	Zfish	PMID:29140250
Biological Process	GO:0038092	nodal signaling pathway	gdf3	IMP	ZFIN:ZDB-GENO-181004-3	Zfish	PMID:29140251
Biological Process	GO:0030903	notochord development	Gdf3	IMP	MGI:MGI:3612535	Mouse	PMID:16368929
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Gdf3	IMP		Mouse	MGI:MGI:5825423|PMID:22223106
Biological Process	GO:0090009	primitive streak formation	Gdf3	IMP	MGI:MGI:3612535	Mouse	PMID:16368929
Biological Process	GO:0010453	regulation of cell fate commitment	GDF3	IDA		Human	PMID:18823971
Biological Process	GO:1904086	regulation of epiboly involved in gastrulation with mouth forming second	gdf3	IMP		Zfish	PMID:24892953|ZFIN:ZDB-PUB-140604-3
Biological Process	GO:1900145	regulation of nodal signaling pathway involved in determination of left/right asymmetry	gdf3	IMP	ZFIN:ZDB-MRPHLNO-140117-1	Zfish	PMID:23791819
Biological Process	GO:0002021	response to dietary excess	Gdf3	IMP	MGI:MGI:3764814	Mouse	PMID:18480259
Biological Process	GO:0007165	signal transduction	Gdf3	IMP	MGI:MGI:3764814	Mouse	PMID:17936261
Biological Process	GO:0001501	skeletal system development	GDF3	IMP		Human	PMID:19864492
Biological Process	GO:0032525	somite rostral/caudal axis specification	Gdf3	IMP	MGI:MGI:3612535	Mouse	PMID:16368929

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern