Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FTH1
  • Mouse genes Fth1
  • Rat genes Fth1
  • Zfish genes fth1a,fth1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fth1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	FTH1	IPI	UniProtKB:P02794	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	FTH1	IPI	UniProtKB:P02794	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	FTH1	IPI	UniProtKB:P02794	Human	PMID:33087927
Molecular Function	GO:0042802	identical protein binding	Fth1	IPI	UniProtKB:P09528	Mouse	MGI:MGI:6730457|PMID:33087931
Molecular Function	GO:0042802	identical protein binding	Fth1	IPI	UniProtKB:P09528	Mouse	MGI:MGI:6827209|PMID:32647824
Molecular Function	GO:0042802	identical protein binding	Fth1	IPI	UniProtKB:P09528	Mouse	MGI:MGI:3609918|PMID:11591653
Molecular Function	GO:0005506	iron ion binding	Fth1	IDA		Mouse	PMID:21886823
Molecular Function	GO:0140315	iron ion sequestering activity	FTH1	IDA		Human	PMID:9924025
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:15607035
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P02792	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P02792	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P51116	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:Q92574	Human	PMID:17355907
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P02786	Human	PMID:20133674
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P61244	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P02792	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:Q9UER7	Human	PMID:21573799
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P51116	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:Q92574	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:Q9UER7	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:Q2Q067	Human	PMID:22458338
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P04792	Human	PMID:25277244
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P02792	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P02792	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P02792	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P02792	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:P51116	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	FTH1	IPI	UniProtKB:O95429	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Fth1	IPI	RGD:620465	Rat	PMID:19244528|RGD:2315109
Cellular Component	GO:0044754	autolysosome	FTH1	IDA		Human	PMID:25327288
Cellular Component	GO:0070062	extracellular exosome	FTH1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	FTH1	HDA		Human	PMID:23533145
Cellular Component	GO:0005739	mitochondrion	Fth1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005634	nucleus	FTH1	HDA		Human	PMID:21630459
Biological Process	GO:0006826	iron ion transport	Fth1	IDA		Mouse	PMID:21886823
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	FTH1	IDA		Human	PMID:9924025
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Fth1	IDA		Rat	PMID:9924025|RGD:8554663
Biological Process	GO:0060547	negative regulation of necrotic cell death	Fth1	IMP		Rat	PMID:18992754|RGD:2315110

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern