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Fth1
Gene Detail
Symbol

Name
ID
Fth1
ferritin heavy chain 1
MGI:95588
Synonyms
FHC, H-ferritin, HFt, MFH
Feature Type
protein coding gene
Genetic Map
Chromosome 19
6.23 cM, cytoband A-C
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr19:9982703-9985092 bp, + strand
From Ensembl annotation of GRCm38

  2390 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74295  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FTH1
Protein SuperFamily: ferritin
Gene Tree: Fth1

Human
homologs
FTH1, ferritin, heavy polypeptide 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2495
neXtProt AC: NX_P02794

Human Synonyms: FHC, FTH, FTHL6, HFE5, PIG15, PLIF

Human Chr (Location): 11q13; chr11:61964285-61967660 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FTH1

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(7) Transgenic(1)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene die as embryos. Mice heterozygous for a knock-out allele exhibit oxidative stress in neurons.
 
Interactions
Fth1 interacts with 33 markers (Mir10a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cellular iron ion homeostasis, intracellular sequestering of iron ion, ...
Component extracellular exosome, mitochondrion, ...
Function ferric iron binding, ferroxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (147)    Tissues (133)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
RT-PCR 2
cDNA source data(1550)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FTH1 ; Xenbase fth1 ; ZFIN fth1a    NEW 
Molecular
reagents
All nucleic(1567) Genomic(7) cDNA(1555) Primer pair(1) Other(4)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024661 (Evidence)
Entrez Gene 14319 (Evidence)
UniGene 1776
DFCI TC1573476, TC1596175, TC1596394, TC1607899, TC1621401
DoTS DT.101250308, DT.101361456, DT.101361613, DT.102554058, DT.103577377, DT.91385358, DT.94255128, DT.94284304
NIA Mouse Gene Index U019149
EC 1.16.3.1
PDB 3WNW
Consensus CDS Project CCDS29567.1
International Mouse Phenotyping Consortium Status Fth1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024661 Ensembl Gene Model | MGI Sequence Detail 2390 C57BL/6J ±  kb
transcript ENSMUST00000025563 Ensembl | MGI Sequence Detail 866 Not Applicable 
polypeptide ENSMUSP00000025563 Ensembl | MGI Sequence Detail 182 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(3) UniProt(1)
Polymorphisms
RFLP(8) : SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001519 Ferritin
InterPro IPR014034 Ferritin, conserved site
InterPro IPR008331 Ferritin/DPS protein domain
InterPro IPR009040 Ferritin- like diiron domain
InterPro IPR009078 Ferritin-like superfamily
InterPro IPR012347 Ferritin-related
Protein Ontology PR:000007690 ferritin heavy chain
References
(Earliest) J:9319 Torti SV, et al., The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene. J Biol Chem. 1988 Sep 5;263(25):12638-44
(Latest) J:216478 Dutra FF, et al., Hemolysis-induced lethality involves inflammasome activation by heme. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4110-8
All references(94)
Other
accession IDs
MGD-MRK-9882, MGI:2141526, MGI:2147632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory