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Fth1 Gene Detail
Summary
  • Symbol
    Fth1
  • Name
    ferritin heavy polypeptide 1
  • Synonyms
    FHC, H-ferritin, HFt, MFH
  • Feature Type
    protein coding gene
  • IDs
    MGI:95588
    NCBI Gene: 14319
  • Gene Overview
    MyGene.info: FTH1
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:9982703-9985092 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 6.23 cM, cytoband A-C
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95588
protein coding gene Chr19:9980600-9985111 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024833
protein coding gene Chr19:7288977-7291366 (+)
A/J MGP_AJ_G0024801
protein coding gene Chr19:6785788-6788208 (+)
AKR/J MGP_AKRJ_G0024776
protein coding gene Chr19:7062251-7064640 (+)
BALB/cJ MGP_BALBcJ_G0024801
protein coding gene Chr19:6831965-6834385 (+)
C3H/HeJ MGP_C3HHeJ_G0024567
protein coding gene Chr19:6942439-6944859 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025249
protein coding gene Chr19:7609291-7611680 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022676
protein coding gene Chr19:7206182-7208535 (+)
CAST/EiJ MGP_CASTEiJ_G0024040
protein coding gene Chr19:6586491-6588924 (+)
CBA/J MGP_CBAJ_G0024541
protein coding gene Chr19:7684204-7686593 (+)
DBA/2J MGP_DBA2J_G0024668
protein coding gene Chr19:6800679-6803068 (+)
FVB/NJ MGP_FVBNJ_G0024635
protein coding gene Chr19:6835395-6837784 (+)
LP/J MGP_LPJ_G0024755
protein coding gene Chr19:7268318-7270707 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024662
protein coding gene Chr19:7579875-7582264 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025297
protein coding gene Chr19:7088111-7090500 (+)
PWK/PhJ MGP_PWKPhJ_G0023785
protein coding gene Chr19:6232083-6234641 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023590
protein coding gene Chr19:6272130-6274553 (+)
WSB/EiJ MGP_WSBEiJ_G0024102
protein coding gene Chr19:6960720-6963140 (+)



Homology
more
  • Human Ortholog
    FTH1, ferritin heavy chain 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    FTH1, ferritin heavy chain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FHC, FTH, FTHL6, HFE5, PIG15, PLIF
  • Links
    NCBI Gene ID: 2495
    neXtProt AC: NX_P02794
    UniProt: P02794

  • Chr Location
    11q12.3; chr11:61964285-61967660 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74295
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;2 macaque, rhesus
  • HCOP
    human homology predictions: FTH1
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human FTH1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 7 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos. Mice heterozygous for a knock-out allele exhibit oxidative stress in neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024661 Ensembl Gene Model | MGI Sequence Detail 2390 C57BL/6J ±  kb
    transcript ENSMUST00000025563 Ensembl | MGI Sequence Detail 866 Not Applicable  
    polypeptide ENSMUSP00000025563 Ensembl | MGI Sequence Detail 182 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1568
      Genomic 7
      cDNA 1556
      Primer pair 1
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9882, MGI:2141526, MGI:2147632
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:9319 Torti SV, et al., The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene. J Biol Chem. 1988 Sep 5;263(25):12638-44
    • Latest
      J:253612 Weis S, et al., Metabolic Adaptation Establishes Disease Tolerance to Sepsis. Cell. 2017 Jun 15;169(7):1263-1275.e14

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory