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Fth1 Gene Detail
Summary
  • Symbol
    Fth1
  • Name
    ferritin heavy polypeptide 1
  • Synonyms
    FHC, H-ferritin, HFt, MFH
  • Feature Type
    protein coding gene
  • IDs
    MGI:95588
    NCBI Gene: 14319
  • Gene Overview
    MyGene.info: FTH1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:9982703-9985092 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2390 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 6.23 cM, cytoband A-C
  • Mapping Data
    26 experiments
Homology
more
  • Human Ortholog
    FTH1, ferritin heavy chain 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    FTH1, ferritin heavy chain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FHC, FTH, FTHL6, HFE5, PIG15, PLIF
  • Links
    NCBI Gene ID: 2495
    neXtProt AC: NX_P02794
    UniProt: P02794

  • Chr Location
    11q12.3; chr11:61964285-61967660 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74295
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;2 macaque, rhesus
  • HCOP
    human homology predictions: FTH1
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human FTH1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 7 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos. Mice heterozygous for a knock-out allele exhibit oxidative stress in neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024661 Ensembl Gene Model | MGI Sequence Detail 2390 C57BL/6J ±  kb
    transcript ENSMUST00000025563 Ensembl | MGI Sequence Detail 866 Not Applicable  
    polypeptide ENSMUSP00000025563 Ensembl | MGI Sequence Detail 182 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      50 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1568
      Genomic 7
      cDNA 1556
      Primer pair 1
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9882, MGI:2141526, MGI:2147632
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:9319 Torti SV, et al., The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene. J Biol Chem. 1988 Sep 5;263(25):12638-44
    • Latest
      J:253612 Weis S, et al., Metabolic Adaptation Establishes Disease Tolerance to Sepsis. Cell. 2017 Jun 15;169(7):1263-1275.e14

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory