Fth1
Gene Detail

Symbol Name ID

Fth1 ferritin heavy chain 1 MGI:95588

Synonyms

FHC, H-ferritin, HFt, MFH

Feature Type

protein coding gene

Genetic Map

Chromosome 19

6.23 cM, cytoband A-C
Detailed Genetic Map ± 1 cM


Mapping data(26)

Sequence Map

Chr19:9982703-9985092 bp, + strand From NCBI annotation of GRCm38   2390 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74295  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 3 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ferritin
Gene Tree: Fth1

Human homologs

Human Homolog		FTH1, ferritin, heavy polypeptide 1
NCBI Gene ID		2495
neXtProt AC		NX_P02794
Human Synonyms		FHC, FTH, FTHL6, PIG15, PLIF
Human Chr (Location)		11q13; chr11:61731757-61735132 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FTH1

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for disruptions in this gene die as embryos. Mice heterozygous for a knock-out allele exhibit oxidative stress in neurons.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cellular iron ion homeostasis, intracellular sequestering of iron ion, ...
Component	mitochondrion
Function	ferric iron binding, ferroxidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (147)    Tissues (133)    Images (27)
Theiler Stages: 15, 17, 19, 20, 22, 23, 28

Assay Type	Results
RNA in situ	145
RT-PCR	2

cDNA source data(1525)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(1542) Genomic(7) cDNA(1530) Primer pair(1) Other(4)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000024661 (Evidence)
Entrez Gene	14319 (Evidence)
UniGene	1776
DFCI	TC1573476, TC1596175, TC1596394, TC1607899, TC1621401
DoTS	DT.101250308, DT.101361456, DT.101361613, DT.102554058, DT.103577377, DT.91385358, DT.94255128, DT.94284304
NIA Mouse Gene Index	U019149
EC	1.16.3.1
Consensus CDS Project	CCDS29567.1
International Mouse Knockout Project Status	Fth1

Sequences

Length	Strain/Species
genomic	14319	NCBI Gene Model | MGI Sequence Detail	2390	C57BL/6J
transcript	NR_073181	RefSeq | MGI Sequence Detail	1511	C57BL/6
polypeptide	P09528	UniProt | EBI | MGI Sequence Detail	182	Not Applicable

All sequences(59) RefSeq(3) UniProt(1)

Polymorphisms

RFLP(8) : SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001519	Ferritin
InterPro	IPR014034	Ferritin, conserved site
InterPro	IPR008331	Ferritin/DPS protein domain
InterPro	IPR009040	Ferritin- like diiron domain
InterPro	IPR012347	Ferritin-related
InterPro	IPR009078	Ferritin/ribonucleotide reductase-like
Protein Ontology	PR:000007690	ferritin heavy chain

Graphical View of Protein Domain Structure

References

(Earliest) J:9319 Torti SV, et al., The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene. J Biol Chem. 1988 Sep 5;263(25):12638-44
(Latest) J:178111 Jeong SY, et al., Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice. PLoS One. 2011;6(10):e25404
All references(92)

Other accession IDs

MGD-MRK-9882, MGI:2141526, MGI:2147632