Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FRAT1
  • Mouse genes Frat1
  • Rat genes Peg12
  • Zfish genes gbp
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Frat1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140678	molecular function inhibitor activity	FRAT1	IDA		Human	PMID:10481074
Molecular Function	GO:0005515	protein binding	FRAT1	IPI	UniProtKB:P49840	Human	PMID:10481074
Molecular Function	GO:0005515	protein binding	FRAT1	IPI	UniProtKB:P49841	Human	PMID:11738041
Molecular Function	GO:0005515	protein binding	FRAT1	IPI	UniProtKB:O14640	Human	PMID:12556519
Molecular Function	GO:0005515	protein binding	FRAT1	IPI	UniProtKB:P49841	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	FRAT1	IPI	UniProtKB:P49840	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	FRAT1	IPI	UniProtKB:P49841	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	FRAT1	IPI	UniProtKB:P49840	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	FRAT1	IPI	UniProtKB:P49841	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	FRAT1	IPI	UniProtKB:P49841	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	Frat1	IPI	PR:Q9WV60	Mouse	PMID:22064483
Cellular Component	GO:0005737	cytoplasm	FRAT1	IDA		Human	PMID:12223487
Cellular Component	GO:0005737	cytoplasm	FRAT1	IDA		Human	PMID:12556519
Cellular Component	GO:0005737	cytoplasm	Frat1	IDA		Mouse	PMID:22064483
Cellular Component	GO:0005829	cytosol	FRAT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	FRAT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FRAT1	IDA		Human	PMID:12223487
Cellular Component	GO:0005634	nucleus	Frat1	IDA		Mouse	PMID:22064483
Biological Process	GO:1904886	beta-catenin destruction complex disassembly	FRAT1	IDA		Human	PMID:10428961
Biological Process	GO:0060070	canonical Wnt signaling pathway	FRAT1	IGI	UniProtKB:O14640,UniProtKB:P49674	Human	PMID:12556519
Biological Process	GO:0000578	embryonic axis specification	Frat1	IDA		Mouse	PMID:10534617
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	FRAT1	IGI	UniProtKB:O14640	Human	PMID:12556519
Biological Process	GO:0006611	protein export from nucleus	Frat1	IDA		Mouse	PMID:22064483
Biological Process	GO:0046825	regulation of protein export from nucleus	FRAT1	IDA		Human	PMID:12223487

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern