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Frat1 Gene Detail
Summary
  • Symbol
    Frat1
  • Name
    frequently rearranged in advanced T cell lymphomas
  • Feature Type
    protein coding gene
  • IDs
    MGI:109450
    NCBI Gene: 14296
  • Gene Overview
    MyGene.info: FRAT1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:41829970-41832583 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 35.30 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    10
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109450
protein coding gene Chr19:41829970-41832583 (.)
129S1/SvImJ no annotation
A/J MGP_AJ_G0036416
pseudogene Chr19:39144617-39145258 (+)
AKR/J MGP_AKRJ_G0036367
pseudogene Chr19:40437918-40438559 (+)
BALB/cJ MGP_BALBcJ_G0036408
pseudogene Chr19:39206867-39207508 (+)
C3H/HeJ MGP_C3HHeJ_G0036100
pseudogene Chr19:40585545-40586186 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036917
pseudogene Chr19:42208591-42209232 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0036072
pseudogene Chr19:44255620-44256261 (+)
DBA/2J MGP_DBA2J_G0036247
pseudogene Chr19:38996895-38997536 (+)
FVB/NJ MGP_FVBNJ_G0036202
pseudogene Chr19:38771950-38772591 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0036203
pseudogene Chr19:43883840-43884481 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FRAT1, FRAT1, WNT signaling pathway regulator
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FRAT1, FRAT1, WNT signaling pathway regulator
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 10023
    neXtProt AC: NX_Q92837
    UniProt: Q92837

  • Chr Location
    10q24.1; chr10:97319265-97321915 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    5 phenotype references
Homozygous mice are healthy and fertile with no obvious abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14296 NCBI Gene Model | MGI Sequence Detail 2614 C57BL/6J ±  kb
transcript NM_008043 RefSeq | MGI Sequence Detail 2614 C57BL/6  
polypeptide P70339 UniProt | EBI | MGI Sequence Detail 274 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR008014 Glycogen synthase kinase-3 binding protein
Molecular
Reagents
less
  • All nucleic 26
    Genomic 2
    cDNA 18
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38495, MGI:2147699
References
more
  • Summaries
    All 33
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:38606 Jonkers J, et al., Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. EMBO J. 1997 Feb 3;16(3):441-50
  • Latest
    J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory