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Frat1 Gene Detail
Summary
  • Symbol
    Frat1
  • Name
    frequently rearranged in advanced T cell lymphomas
  • Feature Type
    protein coding gene
  • IDs
    MGI:109450
    NCBI Gene: 14296
  • Gene Overview
    MyGene.info: FRAT1
Location & Maps
more
  • Sequence Map
    Chr19:41829970-41832583 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2614 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 35.30 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    FRAT1, FRAT1, WNT signaling pathway regulator
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FRAT1, FRAT1, WNT signaling pathway regulator
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 10023
    neXtProt AC: NX_Q92837

  • Chr Location
    10q24.1; chr10:97319265-97321915 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    5 phenotype references
  • All Mutations and Alleles
    2
  • Targeted
    1
  • Transgenic
    1
Homozygous mice are healthy and fertile with no obvious abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060253 VEGA Gene Model | MGI Sequence Detail 2614 C57BL/6J ±  kb
transcript OTTMUST00000147497 VEGA | MGI Sequence Detail 2614 Not Applicable  
polypeptide OTTMUSP00000076760 VEGA | MGI Sequence Detail 274 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    15 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR008014 Glycogen synthase kinase-3 binding protein
Molecular
Reagents
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  • All nucleic 25
    Genomic 2
    cDNA 17
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-38495, MGI:2147699
References
more
  • Summaries
    All 29
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:38606 Jonkers J, et al., Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. EMBO J. 1997 Feb 3;16(3):441-50
  • Latest
    J:183670 Bechard M, et al., Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3beta subcellular localization in pluripotent cells. Mol Cell Biol. 2012 Jan;32(2):288-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory