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Frat1
Gene Detail
Symbol

Name
ID
Frat1
frequently rearranged in advanced T cell lymphomas
MGI:109450
Feature Type
protein coding gene
Genetic Map
Chromosome 19
35.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:41830168-41830809 bp, + strand
From Ensembl annotation of GRCm38

  642 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3999  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: FRAT1
Gene Tree: Frat1

Human
homologs
FRAT1, frequently rearranged in advanced T-cell lymphomas 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10023
neXtProt AC: NX_Q92837

Human Chr (Location): 10q24.1; chr10:97319265-97321915 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
 
Homozygous mice are healthy and fertile with no obvious abnormalities.
 
Interactions
Frat1 interacts with 23 markers (Mir23a, Mir23b, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process embryonic axis specification, protein export from nucleus
Component cytoplasm, nucleus
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (111)    Tissues (92)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
In situ reporter (knock in) 53
Northern blot 16
RT-PCR 18
cDNA source data(17)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase frat2    NEW 
Molecular
reagents
All nucleic(25) Genomic(2) cDNA(17) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000067199 (Evidence)
Entrez Gene 14296 (Evidence)
UniGene 4573
DFCI TC1585150
DoTS DT.490041
NIA Mouse Gene Index U019456
International Mouse Phenotyping Consortium Status Frat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000067199 Ensembl Gene Model | MGI Sequence Detail 642 C57BL/6J ±  kb
transcript ENSMUST00000087155 Ensembl | MGI Sequence Detail 579 Not Applicable 
polypeptide P70339 UniProt | EBI | MGI Sequence Detail 274 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008014 Glycogen synthase kinase-3 binding protein
Protein Ontology PR:000007654 proto-oncogene FRAT1
Graphical View of Protein Domain Structure
References
(Earliest) J:38606 Jonkers J, et al., Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. EMBO J. 1997 Feb 3;16(3):441-50
(Latest) J:183670 Bechard M, et al., Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3beta subcellular localization in pluripotent cells. Mol Cell Biol. 2012 Jan;32(2):288-96
All references(32)
Other
accession IDs
MGD-MRK-38495, MGI:2147699

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory