Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FHL1
  • Mouse genes Fhl1
  • Rat genes Fhl1
  • Zfish genes fhl1a,fhl1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fhl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	FHL1	IPI	UniProtKB:P04156	Human	PMID:18482256
Molecular Function	GO:0005515	protein binding	FHL1	IPI	UniProtKB:P48552	Human	PMID:19401155
Molecular Function	GO:0005515	protein binding	FHL1	IPI	UniProtKB:P04156	Human	PMID:28671123
Molecular Function	GO:0005515	protein binding	Fhl1	IPI	UniProtKB:P31266	Mouse	MGI:MGI:5918600|PMID:24290140
Molecular Function	GO:0044325	transmembrane transporter binding	FHL1	IPI	UniProtKB:P22460	Human	PMID:18281375
Cellular Component	GO:0005737	cytoplasm	FHL1	IDA		Human	PMID:21702045
Cellular Component	GO:0005829	cytosol	FHL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	FHL1	HDA		Human	PMID:21423176
Cellular Component	GO:0005634	nucleus	FHL1	IDA		Human	PMID:21702045
Cellular Component	GO:0005886	plasma membrane	FHL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	FHL1	IDA		Human	PMID:18281375
Cellular Component	GO:0030018	Z disc	fhl1a	IDA		Zfish	PMID:29735270
Biological Process	GO:0055074	calcium ion homeostasis	fhl1b	IMP	ZFIN:ZDB-MRPHLNO-170720-3	Zfish	PMID:28444561
Biological Process	GO:0003209	cardiac atrium morphogenesis	fhl1a	IMP	ZFIN:ZDB-MRPHLNO-140707-2,ZFIN:ZDB-MRPHLNO-140707-3	Zfish	PMID:23438903
Biological Process	GO:0003206	cardiac chamber morphogenesis	fhl1a	IMP	ZFIN:ZDB-MRPHLNO-140707-2,ZFIN:ZDB-MRPHLNO-140707-3	Zfish	PMID:23438903
Biological Process	GO:0048738	cardiac muscle tissue development	fhl1a	IMP	ZFIN:ZDB-MRPHLNO-150622-3	Zfish	PMID:29735270
Biological Process	GO:0003208	cardiac ventricle morphogenesis	fhl1a	IMP	ZFIN:ZDB-MRPHLNO-140707-2,ZFIN:ZDB-MRPHLNO-140707-3	Zfish	PMID:23438903
Biological Process	GO:0031018	endocrine pancreas development	fhl1b	IMP	ZFIN:ZDB-MRPHLNO-150622-4,ZFIN:ZDB-MRPHLNO-160413-8	Zfish	PMID:26845333
Biological Process	GO:0001889	liver development	fhl1b	IMP	ZFIN:ZDB-MRPHLNO-150622-4,ZFIN:ZDB-MRPHLNO-160413-8	Zfish	PMID:26845333
Biological Process	GO:0007626	locomotory behavior	fhl1b	IMP	ZFIN:ZDB-MRPHLNO-150622-4	Zfish	PMID:25866181
Biological Process	GO:0007626	locomotory behavior	fhl1a	IMP	ZFIN:ZDB-MRPHLNO-150622-3	Zfish	PMID:25866181
Biological Process	GO:0030308	negative regulation of cell growth	FHL1	IDA		Human	PMID:21702045
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	FHL1	IDA		Human	PMID:21702045
Biological Process	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	FHL1	IDA		Human	PMID:21702045
Biological Process	GO:1990798	pancreas regeneration	fhl1b	IMP	ZFIN:ZDB-MRPHLNO-150622-4,ZFIN:ZDB-MRPHLNO-160413-8	Zfish	PMID:26845333
Biological Process	GO:0043268	positive regulation of potassium ion transport	FHL1	IDA		Human	PMID:18281375
Biological Process	GO:0003254	regulation of membrane depolarization	FHL1	IDA		Human	PMID:18281375
Biological Process	GO:1901016	regulation of potassium ion transmembrane transporter activity	FHL1	IDA		Human	PMID:18281375
Biological Process	GO:0035914	skeletal muscle cell differentiation	fhl1a	IMP	ZFIN:ZDB-MRPHLNO-140707-2,ZFIN:ZDB-MRPHLNO-140707-3	Zfish	PMID:29521230
Biological Process	GO:0014816	skeletal muscle satellite cell differentiation	fhl1a	IMP	ZFIN:ZDB-MRPHLNO-140707-2,ZFIN:ZDB-MRPHLNO-140707-3	Zfish	PMID:29521230
Biological Process	GO:0007519	skeletal muscle tissue development	fhl1a	IMP	ZFIN:ZDB-MRPHLNO-150622-3	Zfish	PMID:29735270

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern