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Fhl1 Gene Detail
Summary
  • Symbol
    Fhl1
  • Name
    four and a half LIM domains 1
  • Synonyms
    KyoT, KyoT1, KyoT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298387
    NCBI Gene: 14199
  • Gene Overview
    MyGene.info: FHL1
Location & Maps
more
  • Sequence Map
    ChrX:56731787-56793346 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      61560 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FHL1, four and a half LIM domains 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FHL1, four and a half LIM domains 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FHL-1, FHL1A, FHL1B, FLH1A, KYOT, RBMX1A, RBMX1B, SLIM, SLIM1, SLIM-1, SLIMMER, XMPMA
  • Links
    NCBI Gene ID: 2273
    neXtProt AC: NX_Q13642

  • Chr Location
    Xq26; chrX:136146702-136211359 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31038
    1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FHL1
  • Gene Tree
Human Diseases
more
  • Diseases
    4 with human FHL1 associations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    2
  • Targeted
    4
  • Transgenic
    1
Mice homozygous for a null allele exhibit resistance to cardiomyopathy induced by transverse aortic constriction or transgene expression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017580 VEGA Gene Model | MGI Sequence Detail 61560 C57BL/6J ±  kb
transcript OTTMUST00000042746 VEGA | MGI Sequence Detail 2770 Not Applicable  
polypeptide OTTMUSP00000019202 VEGA | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    296 from dbSNP Build 142
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000007513 four and a half LIM domains protein 1
  • PDB
  • InterPro Domains
    IPR001781 Zinc finger, LIM-type
Molecular
Reagents
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  • All nucleic 152
    cDNA 149
    Primer pair 3

    Microarray probesets 5
References
more
  • Summaries
    All 56
    Developmental Gene Expression 14
    Gene Ontology 3
    Phenotypes 17
  • Earliest
    J:49742 Kuroiwa A, et al., Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Cytogenet Cell Genet. 1998;81(3-4):208-12
  • Latest
    J:218097 Emmanuele V, et al., Fhl1 W122S causes loss of protein function and late-onset mild myopathy. Hum Mol Genet. 2015 Feb 1;24(3):714-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory