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Fhl1 Gene Detail
Summary
  • Symbol
    Fhl1
  • Name
    four and a half LIM domains 1
  • Synonyms
    KyoT, KyoT1, KyoT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298387
    NCBI Gene: 14199
  • Gene Overview
    MyGene.info: FHL1
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:56731787-56793346 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 30.06 cM, cytoband A6-A7.1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    296 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298387
protein coding gene ChrX:56731720-56793346 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035740
protein coding gene ChrX:52034672-52097440 (+)
A/J MGP_AJ_G0035723
protein coding gene ChrX:52219636-52285156 (+)
AKR/J MGP_AKRJ_G0035643
protein coding gene ChrX:53615694-53680805 (+)
BALB/cJ MGP_BALBcJ_G0035710
protein coding gene ChrX:51692904-51757410 (+)
C3H/HeJ MGP_C3HHeJ_G0035412
protein coding gene ChrX:52569757-52635960 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036239
protein coding gene ChrX:53419399-53481842 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033090
protein coding gene ChrX:51663366-51723795 (+)
CAST/EiJ MGP_CASTEiJ_G0034705
protein coding gene ChrX:38458431-38548282 (+)
CBA/J MGP_CBAJ_G0035387
protein coding gene ChrX:54974532-55036252 (+)
DBA/2J MGP_DBA2J_G0035541
protein coding gene ChrX:51822097-51883644 (+)
FVB/NJ MGP_FVBNJ_G0035491
protein coding gene ChrX:51419134-51481126 (+)
LP/J MGP_LPJ_G0035629
protein coding gene ChrX:52621141-52685045 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035527
protein coding gene ChrX:56515334-56586438 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036255
protein coding gene ChrX:52064459-52125794 (+)
PWK/PhJ MGP_PWKPhJ_G0034401
protein coding gene ChrX:36730684-36794473 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034245
protein coding gene ChrX:39184413-39251463 (+)
WSB/EiJ MGP_WSBEiJ_G0034848
protein coding gene ChrX:51598589-51660712 (+)



Homology
more
  • Human Ortholog
    FHL1, four and a half LIM domains 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FHL1, four and a half LIM domains 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FCMSU, FHL-1, FHL1A, FHL1B, FLH1A, KYOT, RBMX1A, RBMX1B, SLIM, SLIM1, SLIM-1, SLIMMER, XMPMA
  • Links
    NCBI Gene ID: 2273
    neXtProt AC: NX_Q13642
    UniProt: Q13642

  • Chr Location
    Xq26.3; chrX:136146702-136211359 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31038
    1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FHL1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Fhl1 mouse models; 3 with human FHL1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit resistance to cardiomyopathy induced by transverse aortic constriction or transgene expression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023092 Ensembl Gene Model | MGI Sequence Detail 61560 C57BL/6J ±  kb
    transcript ENSMUST00000114769 Ensembl | MGI Sequence Detail 2770 Not Applicable  
    polypeptide ENSMUSP00000110417 Ensembl | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • PDB
    • InterPro Domains
      IPR001781 Zinc finger, LIM-type
    Molecular
    Reagents
    less
    • All nucleic 154
      cDNA 150
      Primer pair 3
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 3
      Phenotypes 20
    • Earliest
      J:49742 Kuroiwa A, et al., Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Cytogenet Cell Genet. 1998;81(3-4):208-12
    • Latest
      J:258479 Krysiak J, et al., Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. Nat Commun. 2018 Jan 17;9(1):262

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory