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Fhl1
Gene Detail
Symbol

Name
ID
Fhl1
four and a half LIM domains 1
MGI:1298387
Synonyms
KyoT, KyoT1, KyoT2
Feature Type
protein coding gene
Genetic Map
Chromosome X
30.06 cM, cytoband A6-A7.1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:56731787-56793346 bp, + strand
From VEGA annotation of GRCm38

  61560 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31038  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FHL1
Gene Tree: Fhl1

Human
homologs
FHL1, four and a half LIM domains 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2273
neXtProt AC: NX_Q13642

Human Synonyms: FHL-1, FHL1A, FHL1B, FLH1A, KYOT, SLIM, SLIM1, SLIM-1, SLIMMER, XMPMA

Human Chr (Location): Xq26; chrX:136146702-136211359 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human FHL1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
 
Mice homozygous for a null allele exhibit resistance to cardiomyopathy induced by transverse aortic constriction or transgene expression.
 
Interactions
Fhl1 interacts with 206 markers (Mir7-1, Mir15b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell differentiation, multicellular organismal development, ...
Component cytoplasm, focal adhesion, ...
Function ion channel binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (339)    Tissues (201)    Images (81)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 306
In situ reporter (knock in) 9
Northern blot 12
RT-PCR 12
cDNA source data(147)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fhl1 ; ZFIN fhl1a, fhl1b    NEW 
Molecular
reagents
All nucleic(152) cDNA(149) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017580 (Evidence)
Ensembl Gene Model ENSMUSG00000023092 (Evidence)
Entrez Gene 14199 (Evidence)
UniGene 3126
DFCI TC1575023, TC1598378
DoTS DT.94346495, DT.97410792, DT.536644, DT.101713520
NIA Mouse Gene Index U019865
PDB 4J2X
Consensus CDS Project CCDS30148.1, CCDS40980.1, CCDS40981.1
International Mouse Phenotyping Consortium Status Fhl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017580 VEGA Gene Model | MGI Sequence Detail 61560 C57BL/6J ±  kb
transcript OTTMUST00000042746 VEGA | MGI Sequence Detail 2770 Not Applicable 
polypeptide OTTMUSP00000019202 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(26) UniProt(8)
Polymorphisms
SNPs within 2kb(295 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000007513 four and a half LIM domains protein 1
References
(Earliest) J:49742 Kuroiwa A, et al., Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Cytogenet Cell Genet. 1998;81(3-4):208-12
(Latest) J:209422 Christodoulou DC, et al., 5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy. J Clin Invest. 2014 Mar 3;124(3):1364-70
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory