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Fhl1
Gene Detail
Symbol

Name
ID
Fhl1
four and a half LIM domains 1
MGI:1298387
Synonyms
KyoT, KyoT1, KyoT2
Feature Type
protein coding gene
Genetic Map
Chromosome X
30.06 cM, cytoband A6-A7.1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:56731787-56793346 bp, + strand
From VEGA annotation of GRCm38

  61560 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31038  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fhl1

Human
homologs
Human Homolog FHL1, four and a half LIM domains 1
NCBI Gene ID 2273
neXtProt AC  NX_Q13642
Human Synonyms  FHL-1, FHL1A, FHL1B, FLH1A, KYOT, SLIM, SLIM1, SLIM-1, SLIMMER, XMPMA
Human Chr (Location)  Xq26; chrX:136146702-136211359 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human FHL1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
 
Mice homozygous for a null allele exhibit resistance to cardiomyopathy induced by transverse aortic constriction or transgene expression.
 
Interactions
Fhl1 interacts with 206 markers (Mir7-1, Mir15b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell differentiation, multicellular organismal development, ...
Component cytoplasm, focal adhesion, ...
Function ion channel binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (339)    Tissues (201)    Images (81)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 306
In situ reporter (knock in) 9
Northern blot 12
RT-PCR 12
cDNA source data(147)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(152) cDNA(149) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017580 (Evidence)
Ensembl Gene ModelENSMUSG00000023092 (Evidence)
Entrez Gene14199 (Evidence)
UniGene3126
DFCITC1575023, TC1598378
DoTSDT.101713520, DT.536644, DT.94346495, DT.97410792
NIA Mouse Gene IndexU019865
PDB4J2X
Consensus CDS ProjectCCDS30148.1, CCDS40980.1, CCDS40981.1
International Mouse Knockout Project StatusFhl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017580 VEGA Gene Model | MGI Sequence Detail 61560 C57BL/6J ±  kb
transcript OTTMUST00000042746 VEGA | MGI Sequence Detail 2770 Not Applicable 
polypeptide OTTMUSP00000019202 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(28) UniProt(8)
Polymorphisms
SNPs within 2kb(295 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000007513 four and a half LIM domains protein 1
References
(Earliest) J:49742 Kuroiwa A, et al., Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Cytogenet Cell Genet. 1998;81(3-4):208-12
(Latest) J:203119 Domenighetti AA, et al., Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Hum Mol Genet. 2014 Jan 1;23(1):209-25
All references(60)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory